Behnood, S;
Newlands, F;
O'Mahoney, L;
Haghighat Ghahfarokhi, M;
Muhid, MZ;
Dudley, J;
Stephenson, T;
Ladhani, SN;
Bennett, S;
Viner, RM;
et al.
Behnood, S; Newlands, F; O'Mahoney, L; Haghighat Ghahfarokhi, M; Muhid, MZ; Dudley, J; Stephenson, T; Ladhani, SN; Bennett, S; Viner, RM; Bhopal, R; Kolasinska, P; Shafran, R; Swann, OV; Takeda, A
(2023)
Persistent symptoms are associated with long term effects of COVID-19 among children and young people: Results from a systematic review and meta-analysis of controlled studies.
PLoS One, 18 (12).
e0293600.
ISSN 1932-6203
https://doi.org/10.1371/journal.pone.0293600
SGUL Authors: Ladhani, Shamez Nizarali
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Abstract
BACKGROUND: Research on the long-term impact on COVID-19 in children and young people (CYP) has been published at pace. We aimed to update and refine an earlier systematic review and meta-analysis to assess the current evidence for Post-COVID-19 Condition in CYP. METHODS: Studies from the previous systematic review were combined with studies from a systematic search from July 2021 to November 2022 (registration PROSPERO CRD42021233153). Eligible studies included CYP aged ≤19 years with confirmed or probable SARS-CoV-2 infection and symptoms persisting at least 12 weeks. FINDINGS: 55 studies (n = 1,139,299 participants) were included. Over two-hundred symptoms were associated with Post COVID-19 Condition. Gastrointestinal problems, headaches, cough and fever were among the most prevalent symptoms with rates of 50.2%, 35.6%, 34.7% and 25.8% respectively. Twenty-one symptoms from 11 studies were suitable for meta-analysis. There were significantly higher pooled estimates of proportions of symptoms for altered / loss of smell or taste, dyspnoea, fatigue, and myalgia in CYP with confirmed SARS-CoV-2 infection. Heterogeneity was high suggesting substantial variation amongst the included studies. CONCLUSIONS: Many CYP continue to experience symptoms after SARS-CoV-2 infection. Efforts to aid early identification and intervention of those most in need is warranted and the consequences of COVID-19 for CYP call for long-term follow-up.
Item Type: | Article | ||||||||||||||||||
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Additional Information: | © 2023 Behnood et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | ||||||||||||||||||
Keywords: | Child, Humans, Adolescent, COVID-19, SARS-CoV-2, Headache, Research Design, Gastrointestinal Diseases, Post-Acute COVID-19 Syndrome | ||||||||||||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) | ||||||||||||||||||
Journal or Publication Title: | PLoS One | ||||||||||||||||||
Editors: | Yon, Dong Keon | ||||||||||||||||||
ISSN: | 1932-6203 | ||||||||||||||||||
Language: | eng | ||||||||||||||||||
Media of Output: | Electronic-eCollection | ||||||||||||||||||
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Publisher License: | Creative Commons: Attribution 4.0 | ||||||||||||||||||
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URI: | https://openaccess.sgul.ac.uk/id/eprint/117561 | ||||||||||||||||||
Publisher's version: | https://doi.org/10.1371/journal.pone.0293600 |
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