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Persistent symptoms are associated with long term effects of COVID-19 among children and young people: Results from a systematic review and meta-analysis of controlled studies.

Behnood, S; Newlands, F; O'Mahoney, L; Haghighat Ghahfarokhi, M; Muhid, MZ; Dudley, J; Stephenson, T; Ladhani, SN; Bennett, S; Viner, RM; et al. Behnood, S; Newlands, F; O'Mahoney, L; Haghighat Ghahfarokhi, M; Muhid, MZ; Dudley, J; Stephenson, T; Ladhani, SN; Bennett, S; Viner, RM; Bhopal, R; Kolasinska, P; Shafran, R; Swann, OV; Takeda, A (2023) Persistent symptoms are associated with long term effects of COVID-19 among children and young people: Results from a systematic review and meta-analysis of controlled studies. PLoS One, 18 (12). e0293600. ISSN 1932-6203 https://doi.org/10.1371/journal.pone.0293600
SGUL Authors: Ladhani, Shamez Nizarali

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Abstract

BACKGROUND: Research on the long-term impact on COVID-19 in children and young people (CYP) has been published at pace. We aimed to update and refine an earlier systematic review and meta-analysis to assess the current evidence for Post-COVID-19 Condition in CYP. METHODS: Studies from the previous systematic review were combined with studies from a systematic search from July 2021 to November 2022 (registration PROSPERO CRD42021233153). Eligible studies included CYP aged ≤19 years with confirmed or probable SARS-CoV-2 infection and symptoms persisting at least 12 weeks. FINDINGS: 55 studies (n = 1,139,299 participants) were included. Over two-hundred symptoms were associated with Post COVID-19 Condition. Gastrointestinal problems, headaches, cough and fever were among the most prevalent symptoms with rates of 50.2%, 35.6%, 34.7% and 25.8% respectively. Twenty-one symptoms from 11 studies were suitable for meta-analysis. There were significantly higher pooled estimates of proportions of symptoms for altered / loss of smell or taste, dyspnoea, fatigue, and myalgia in CYP with confirmed SARS-CoV-2 infection. Heterogeneity was high suggesting substantial variation amongst the included studies. CONCLUSIONS: Many CYP continue to experience symptoms after SARS-CoV-2 infection. Efforts to aid early identification and intervention of those most in need is warranted and the consequences of COVID-19 for CYP call for long-term follow-up.

Item Type: Article
Additional Information: © 2023 Behnood et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Child, Humans, Adolescent, COVID-19, SARS-CoV-2, Headache, Research Design, Gastrointestinal Diseases, Post-Acute COVID-19 Syndrome
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: PLoS One
Editors: Yon, Dong Keon
ISSN: 1932-6203
Language: eng
Media of Output: Electronic-eCollection
Related URLs:
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
Sponsor reference: W1168; Award number: 183885Beryl Alexander CharityUNSPECIFIED
UNSPECIFIEDWorld Health Organizationhttp://dx.doi.org/10.13039/100004423
COV-LT-0022National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
COV-LT-0022UK Research and Innovationhttps://doi.org/10.13039/100014013
NIHR203752National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
URI: https://openaccess.sgul.ac.uk/id/eprint/117561
Publisher's version: https://doi.org/10.1371/journal.pone.0293600

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