Abstract

OBJECTIVE: To assess the impact of the Fetal Medicine Foundation (FMF) first trimester screening algorithm for pre-eclampsia on health disparities for perinatal death amongst minority ethnic groups. DESIGN: A retrospective cohort study from July 2016 to December 2020. SETTING: A large London teaching hospital. PATIENTS AND METHODS: All women who underwent first trimester pre-eclampsia risk assessment using either the NICE screening checklist or the FMF multimodal approach. Women considered at high-risk in the FMF cohort were offered 150mg aspirin before 16 weeks' gestation, serial growth scans and elective birth at 40 weeks. MAIN OUTCOME MEASURES: Stillbirth, neonatal death and perinatal death rates stratified by screening method and maternal ethnicity. RESULTS: In the NICE cohort, the perinatal death rate was significantly higher in non-White versus White women (7.95/1000 vs 2.63/1000 births, OR 3.035, 95% CI 1.551 to 5.941). Following the introduction of FMF screening, the perinatal death rate in non-White women fell from 7.95 to 3.22/1000 births (OR 0.403, 95% CI 0.206 to 0.789), such that it was no longer significantly different from the perinatal mortality rate in White women (3.22/1000 vs 2.55/1000 births, OR 1.261, 95% CI 0.641 to 2.483). CONCLUSIONS: First trimester combined screening for placental dysfunction is associated with a significant reduction in perinatal death in minority ethnic women. Health disparity for perinatal death amongst ethnic minority women demands urgent attention from both clinicians and health policy makers. The data of this study suggests that this ethnic health inequality may be avoidable.