Savage, HR;
Santos, VS;
Edwards, T;
Giorgi, E;
Krishna, S;
Planche, TD;
Staines, HM;
Fitchett, JRA;
Kirwan, DE;
Cubas Atienzar, AI;
et al.
Savage, HR; Santos, VS; Edwards, T; Giorgi, E; Krishna, S; Planche, TD; Staines, HM; Fitchett, JRA; Kirwan, DE; Cubas Atienzar, AI; Clark, DJ; Adams, ER; Cuevas, LE
(2021)
Prevalence of neutralising antibodies against SARS-CoV-2 in acute infection and convalescence: A systematic review and meta-analysis.
PLoS Negl Trop Dis, 15 (7).
e0009551.
ISSN 1935-2735
https://doi.org/10.1371/journal.pntd.0009551
SGUL Authors: Krishna, Sanjeev Staines, Henry Michael Planche, Timothy David
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Abstract
BACKGROUND: Individuals infected with SARS-CoV-2 develop neutralising antibodies. We investigated the proportion of individuals with SARS-CoV-2 neutralising antibodies after infection and how this proportion varies with selected covariates. METHODOLOGY/PRINCIPAL FINDINGS: This systematic review and meta-analysis examined the proportion of individuals with SARS-CoV-2 neutralising antibodies after infection and how these proportions vary with selected covariates. Three models using the maximum likelihood method assessed these proportions by study group, covariates and individually extracted data (protocol CRD42020208913). A total of 983 reports were identified and 27 were included. The pooled (95%CI) proportion of individuals with neutralising antibodies was 85.3% (83.5-86.9) using the titre cut off >1:20 and 83.9% (82.2-85.6), 70.2% (68.1-72.5) and 54.2% (52.0-56.5) with titres >1:40, >1:80 and >1:160, respectively. These proportions were higher among patients with severe COVID-19 (e.g., titres >1:80, 84.8% [80.0-89.2], >1:160, 74.4% [67.5-79.7]) than those with mild presentation (56.7% [49.9-62.9] and 44.1% [37.3-50.6], respectively) and lowest among asymptomatic infections (28.6% [17.9-39.2] and 10.0% [3.7-20.1], respectively). IgG and neutralising antibody levels correlated poorly. CONCLUSIONS/SIGNIFICANCE: 85% of individuals with proven SARS-CoV-2 infection had detectable neutralising antibodies. This proportion varied with disease severity, study setting, time since infection and the method used to measure antibodies.
Item Type: | Article | |||||||||
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Additional Information: | Copyright: © 2021 Savage et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||||
Keywords: | 06 Biological Sciences, 11 Medical and Health Sciences, Tropical Medicine | |||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) | |||||||||
Journal or Publication Title: | PLoS Negl Trop Dis | |||||||||
ISSN: | 1935-2735 | |||||||||
Language: | eng | |||||||||
Dates: |
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Publisher License: | Creative Commons: Attribution 4.0 | |||||||||
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PubMed ID: | 34237072 | |||||||||
Web of Science ID: | WOS:000674292300010 | |||||||||
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URI: | https://openaccess.sgul.ac.uk/id/eprint/113452 | |||||||||
Publisher's version: | https://doi.org/10.1371/journal.pntd.0009551 |
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