Abstract

Background Mounting evidence points to stress being a transdiagnostic contributing factor to health conditions. Given the health significance of stress, characterizing macro-level spatiotemporal trends and disparities of stress is necessary to understanding stress and its potential health burden across populations. The need to investigate structural factors contributing to stress is further underscored by the escalating instability worldwide over the past decade, which can trigger a stress response and lead to adverse health outcomes if left unaddressed. Methods This study used nationally representative surveys (N = 2461,226; 146 countries) in 2006–2023 and the Fragile State Index (N = 137 countries) to i) describe global stress trends varied by world regions and demographic groups, and ii) examine whether nation-level state fragility, a summative measure that aggregates 12 economic, social, and political indicators to assess a state’s risk of collapse or conflict, predicts steeper increases in stress over time. Results A state’s level of fragility may contribute to individuals’ perceived stress and in turn have profound consequences for population physical and mental health. The current study reveals an alarming increase in stress globally and calls for prioritizing structural approaches to reverse this trend. By doing so, we not only reduce stress but also its related disease burden.