Hatherley, J; Collinson, P; Shantsila, E; Gaze, D; Khand, A
(2025)
Clinical impact of current evidence on cardiac troponin structure, function and release mechanisms – An up to date review.
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine.
p. 45632251378025.
ISSN 0004-5632
https://doi.org/10.1177/00045632251378025
SGUL Authors: Collinson, Paul
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Abstract
Myocardial infarction remains a significant cause of mortality globally. High-sensitivity cardiac troponin is an essential criterion in the fourth universal definition of myocardial infarction. Our understanding of the structure and release mechanisms of troponin has been updated over the last decade, facilitated by ever more sensitive assays. This review initially outlines the structure and function of the troponin complex, then details the currently proposed mechanisms of release and elimination of troponin. It concludes by using this updated understanding to critique the current universal definition of myocardial infarction and injury.
| Item Type: | Article | ||||||
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| Additional Information: | Hatherley, J; Collinson, P; Shantsila, E; Gaze, D; Khand, A; Clinical impact of current evidence on cardiac troponin structure, function and release mechanisms – An up to date review, Annals of Clinical Biochemistry. Copyright © 2025 (The Author(s)). DOI: 10.1177/00045632251378025. | ||||||
| Keywords: | Troponin, metabolism, myocardial infarction, myocardial injury, release mechanisms, structure and function | ||||||
| SGUL Research Institute / Research Centre: | Academic Structure > Cardiovascular & Genomics Research Institute Academic Structure > Cardiovascular & Genomics Research Institute > Clinical Cardiology |
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| Journal or Publication Title: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine | ||||||
| ISSN: | 0004-5632 | ||||||
| Language: | en | ||||||
| Media of Output: | Print-Electronic | ||||||
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| Publisher License: | Publisher's own licence | ||||||
| PubMed ID: | 40877034 | ||||||
| Dates: |
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| URI: | https://openaccess.sgul.ac.uk/id/eprint/117932 | ||||||
| Publisher's version: | https://doi.org/10.1177/00045632251378025 |
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