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Cardiac rhythm devices in heart failure with reduced ejection fraction – role, timing, and optimal use in contemporary practice. European Journal of Heart Failure expert consensus document

Bozkurt, B; Mullens, W; Leclercq, C; Russo, AM; Savarese, G; Böhm, M; Hill, L; Kinugawa, K; Sato, N; Abraham, WT; et al. Bozkurt, B; Mullens, W; Leclercq, C; Russo, AM; Savarese, G; Böhm, M; Hill, L; Kinugawa, K; Sato, N; Abraham, WT; Bayes‐Genis, A; Mebazaa, A; Rosano, GMC; Zieroth, S; Linde, C; Butler, J (2025) Cardiac rhythm devices in heart failure with reduced ejection fraction – role, timing, and optimal use in contemporary practice. European Journal of Heart Failure expert consensus document. European Journal of Heart Failure, 27 (7). pp. 1242-1261. ISSN 1388-9842 https://doi.org/10.1002/ejhf.3641
SGUL Authors: Rosano, Giuseppe Massimo Claudio

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Abstract

Guidelines for management of heart failure with reduced ejection fraction (HFrEF) emphasize personalized care, patient engagement, and shared decision‐making. Medications and cardiac rhythm management (CRM) devices are recommended with a high level of evidence. However, there are significant disparities: patients who could benefit from devices are frequently referred too late or not at all. Misconceptions about device therapy and the notion that the needs of patients (especially the prevention of sudden cardiac death) can now be met by expanding drug therapies may play a role in these disparities. This state‐of‐the‐art review is produced by members of the DIRECT HF initiative, a patient‐centred, expert‐led educational programme that aims to advance guideline‐directed use of CRM devices in patients with HFrEF. This review discusses the latest evidence on the role of CRM devices in reducing HFrEF mortality and morbidity, and provides practical guidance on patient referral, device selection, implant timing and patient‐centred follow‐up.

Item Type: Article
Additional Information: © 2025 The Author(s). European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Keywords: Cardiac dyssynchrony, Cardiac implantable electronic device, Cardiac resynchronization therapy, Implantable cardioverter‐defibrillator, Patient‐centred heart failure care, Sudden cardiac death, Humans, Heart Failure, Stroke Volume, Consensus, Defibrillators, Implantable, Cardiac Resynchronization Therapy, Europe
SGUL Research Institute / Research Centre: Academic Structure > Cardiovascular & Genomics Research Institute
Academic Structure > Cardiovascular & Genomics Research Institute > Experimental Cardiology
Journal or Publication Title: European Journal of Heart Failure
ISSN: 1388-9842
Language: en
Media of Output: Print-Electronic
Related URLs:
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Dates:
Date Event
2025-08-21 Published
2025-04-09 Published Online
2025-02-23 Accepted
URI: https://openaccess.sgul.ac.uk/id/eprint/117871
Publisher's version: https://doi.org/10.1002/ejhf.3641

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