Kozhuharov, N;
Karim, N;
Creta, A;
Leung, LWM;
Veasey, R;
Osmanagic, A;
Kefala, A;
Pope, M;
Vouliotis, A;
Knecht, S;
et al.
Kozhuharov, N; Karim, N; Creta, A; Leung, LWM; Veasey, R; Osmanagic, A; Kefala, A; Pope, M; Vouliotis, A; Knecht, S; Krisai, P; Jaïs, P; Martin, C; Sticherling, C; Ginks, M; Ullah, W; Balasubramaniam, R; Kalla, M; Gallagher, MM; Hunter, RJ; Wong, T; Gupta, D
(2024)
Long-term outcomes of catheter ablation for atrial fibrillation in octogenarians.
J Interv Card Electrophysiol.
ISSN 1572-8595
https://doi.org/10.1007/s10840-024-01879-8
SGUL Authors: Gallagher, Mark Michael
Abstract
BACKGROUND AND AIMS: Catheter ablation is superior to pharmacological therapy in controlling atrial fibrillation (AF). There are few data on the long-term outcome of AF ablation in octogenarian patients. This analysis aims to evaluate the outcome of AF ablation in octogenarians vs. younger patients. METHODS: In this retrospective study in 13 centres in the UK, France, and Switzerland, the long-term outcomes of 473 consecutive octogenarian patients undergoing ablation for AF were compared to 473 matched younger controls (median age 81.3 [80.0, 83.0] vs. 64.4 [56.5, 70.7] years, 54.3% vs. 35.1% females; p-value for both < 0.001). The primary endpoint was the recurrence of atrial arrhythmia after a blanking period of 90 days within 365 days of follow-up. RESULTS: Acute ablation success as defined as isolation of all pulmonary veins was achieved in 97% of octogenarians. Octogenarians experienced more procedural complications (11.4% vs 7.0%, p = 0.018). The median follow-up time was 281 [106, 365] days vs. 354 [220, 365] days for octogenarians vs. non-octogenarians (p < 0.001). Among octogenarians, 27.7% (131 patients) experienced a recurrence of atrial arrhythmia, in contrast to 23.5% (111 patients) in the younger group (odds ratio 1.49; 95% confidence interval 1.16-1.92; p = 0.002). In a multivariable regression model including gender, previous AF ablation, vascular disease, chronic kidney disease, CHA2DS2-VASc score, left atrial dilatation, and indwelling cardiac implantable electronic device, age above 80 remained an independent predictor of recurrence of arrhythmia. CONCLUSION: Ablation for AF is effective in octogenarians, but is associated with slightly higher procedural complication rate and recurrence of atrial arrhythmia than in younger patients.
Item Type: |
Article
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Additional Information: |
© The Author(s) 2024
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
Keywords: |
Atrial fibrillation ablation, Octogenarians, Prognosis, Atrial fibrillation ablation, Prognosis, Octogenarians, 1102 Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology |
Journal or Publication Title: |
J Interv Card Electrophysiol |
ISSN: |
1572-8595 |
Language: |
eng |
Dates: |
Date | Event |
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14 August 2024 | Published Online | 14 July 2024 | Accepted |
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Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
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PubMed ID: |
39141267 |
Web of Science ID: |
WOS:001291569100001 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/116790 |
Publisher's version: |
https://doi.org/10.1007/s10840-024-01879-8 |
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