Biddle, K; Nathan, J; Sandhu, V
(2023)
Treatment of gangrenous digit-threatening paraneoplastic acrocyanosis with vasodilator therapy.
BMJ Case Rep, 16 (2).
e251417.
ISSN 1757-790X
https://doi.org/10.1136/bcr-2022-251417
SGUL Authors: Biddle, Kathryn Sandhu, Virinderjit
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Abstract
A man in his 70s, with a recent diagnosis of transitional cell carcinoma of the bladder, reported a 2-month history of discolouration, pain and paraesthesia affecting his fingers. Clinical assessment noted peripheral acrocyanosis with areas of digital ulceration and gangrene. Following further work-up to evaluate potential causes, he was diagnosed with paraneoplastic acrocyanosis. He proceeded to undergo robotic cystoprostatectomy and received adjuvant chemotherapy for the management of his cancer. In parallel to the chemotherapy, vasodilatory therapy was administered as two courses of intravenous synthetic prostacyclin analogue iloprost along with sildenafil. This resulted in a significant improvement in digital pain and gangrene with healing of ulceration.
Item Type: | Article | ||||||||
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Additional Information: | This article has been accepted for publication in BMJ Case Reports, 2023 following peer review, and the Version of Record can be accessed online at https://doi.org/10.1136/bcr-2022-251417 © BMJ Publishing Group Limited 2023. | ||||||||
Keywords: | Oncology, Rheumatology, Male, Humans, Vasodilator Agents, Gangrene, Iloprost, Epoprostenol, Sildenafil Citrate, Humans, Gangrene, Epoprostenol, Iloprost, Vasodilator Agents, Male, Sildenafil Citrate, Oncology, Rheumatology, Epoprostenol, Gangrene, Humans, Iloprost, Male, Sildenafil Citrate, Vasodilator Agents, Oncology, Rheumatology, 1103 Clinical Sciences | ||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) Academic Structure > Institute of Medical & Biomedical Education (IMBE) |
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Journal or Publication Title: | BMJ Case Rep | ||||||||
ISSN: | 1757-790X | ||||||||
Language: | eng | ||||||||
Dates: |
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Publisher License: | Publisher's own licence | ||||||||
PubMed ID: | 36810331 | ||||||||
Web of Science ID: | WOS:000938418700005 | ||||||||
Go to PubMed abstract | |||||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/116763 | ||||||||
Publisher's version: | https://doi.org/10.1136/bcr-2022-251417 |
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