Mortimer, C; Nikoletou, D; Ooms, A; Williams, J
(2023)
Effects of nebulised beta-2 agonists on clinical observations in asthma exacerbations.
Journal of Paramedic Practice, 15 (2).
pp. 1-11.
ISSN 1759-1376
https://doi.org/10.12968/jpar.2023.15.2.cpd1
SGUL Authors: Nikoletou, Dimitra
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Abstract
Background: Despite concerns over their side effects, short-acting beta-2 agonists are still used in high doses in prehospital care internationally to treat asthma exacerbations. This systematic review set out to identify the physiological effects associated with this treatment and determine their potential impact on the patient's presenting or underlying conditions. Methods: A systematic search of literature published from 2010 to 2020 focusing on asthmatic patients receiving nebulised beta-2 agonists during an acute exacerbation was undertaken and relevant articles reviewed. Findings: Eight out of 897 studies met the inclusion criteria. While the studies were heterogeneous with a range of outcome measures, synthesis showed evidence of bronchodilator action throughout, with reductions in potassium levels and cardiovascular changes reported in several studies. Conclusions: Therapeutic effects demonstrated within the data support the use of nebulised beta-2 agonists in these patients and, while adverse effects are frequently seen in the cardiovascular and endocrine systems, their impact on the patient's overall condition remains unclear.
Item Type: | Article | ||||||||
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Additional Information: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Paramedic Practice, copyright © MA Healthcare, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.12968/jpar.2023.15.2.CPD1. | ||||||||
Keywords: | 1103 Clinical Sciences, 1117 Public Health and Health Services | ||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Institute of Medical & Biomedical Education (IMBE) | ||||||||
Journal or Publication Title: | Journal of Paramedic Practice | ||||||||
ISSN: | 1759-1376 | ||||||||
Language: | en | ||||||||
Dates: |
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Publisher License: | Publisher's own licence | ||||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/115239 | ||||||||
Publisher's version: | https://doi.org/10.12968/jpar.2023.15.2.cpd1 |
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