Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae.

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Hu, Y; Coates, A (2021) Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae. J Antimicrob Chemother, 76 (9). pp. 2302-2305. ISSN 1460-2091 https://doi.org/10.1093/jac/dkab184
SGUL Authors: Coates, Anthony Robert Milnes Hu, Yanmin

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Official URL: https://doi.org/10.1093/jac/dkab184

Abstract

OBJECTIVES: To investigate the efficacy of zidovudine in combination with carbapenems against NDM-1-producing Enterobacteriaceae. METHODS: MICs were determined using the broth microdilution method. The combinatory effects of zidovudine and carbapenems were examined using the chequerboard method and time-kill analysis. RESULTS: We found that the NDM-1-producing strains were resistant to all carbapenems tested. FIC index from chequerboard assay demonstrated that zidovudine synergized with carbapenems against all the NDM-1 strains. Time-kill analysis demonstrated significant synergistic activity when a low level of zidovudine was combined with meropenem. CONCLUSIONS: Zidovudine in combination with carbapenems produced synergistic activity against NDM-1 Enterobacteriaceae strains in vitro.

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© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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