Parry-Williams, G; Gati, S; Sharma, S
(2021)
The heart of the ageing endurance athlete: the role of chronic coronary stress.
Eur Heart J, 42 (28).
pp. 2737-2744.
ISSN 1522-9645
https://doi.org/10.1093/eurheartj/ehab095
SGUL Authors: Sharma, Sanjay
|
PDF
Published Version
Available under License Creative Commons Attribution Non-commercial. Download (541kB) | Preview |
|
![]() |
Microsoft Word (.docx) (Supplementary data)
Published Version
Available under License Creative Commons Attribution Non-commercial. Download (26kB) |
|
![]() |
Microsoft Word (.docx)
Accepted Version
Available under License Creative Commons Attribution Non-commercial. Download (103kB) |
Abstract
Moderate physical exercise is associated with an irrefutable reduction in cardiac morbidity and mortality. The current guidelines recommend at least 150 min of moderate exercise or 75 min of vigorous exercise per week. Endurance athletes perform exercise at a level that is 10- to 20-fold greater than these recommendations. These athletes reveal several structural and functional cardiac adaptations including increased cardiac size, enhanced ventricular filling, and augmentation of stroke volume even at the highest heart rates. The long-term effects of endurance exercise on the heart are unknown. Endurance exercise is associated with a transient increase in serum concentrations of biomarkers of cardiac damage and ventricular dysfunction which improves within 72 h. Over the past decade, there have been emerging studies reporting attenuated mortality benefit amongst individuals who perform the highest volume of exercise. Studies in lifelong male athletes aged above 40 years old show a higher prevalence of high coronary artery calcium scores (>300 Agatston units), a higher coronary plaque burden, and myocardial fibrosis compatible with subclinical myocardial infarction compared with relatively sedentary healthy controls, raising speculation that lifelong intense exercise imposes chronic coronary stress on the heart. This review article will provide a critical analysis of the existing data.
Item Type: | Article | ||||||||
---|---|---|---|---|---|---|---|---|---|
Additional Information: | © The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com | ||||||||
Keywords: | Athlete’s heart, Coronary artery calcification, Coronary artery disease, Master athlete, Myocardial fibrosis, Cardiovascular System & Hematology, 1102 Cardiorespiratory Medicine and Haematology | ||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) | ||||||||
Journal or Publication Title: | Eur Heart J | ||||||||
ISSN: | 1522-9645 | ||||||||
Language: | eng | ||||||||
Dates: |
|
||||||||
Publisher License: | Creative Commons: Attribution-Noncommercial 4.0 | ||||||||
Projects: |
|
||||||||
PubMed ID: | 33748860 | ||||||||
Go to PubMed abstract | |||||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/113119 | ||||||||
Publisher's version: | https://doi.org/10.1093/eurheartj/ehab095 |
Statistics
Actions (login required)
![]() |
Edit Item |