da Silva, MB; Urrego A, JR; Oviedo, Y; Cooper, PJ; Pacheco, LGC; Pinheiro, CS; Ferreira, F; Briza, P; Alcantara-Neves, NM
(2018)
The somatic proteins of Toxocara canis larvae and excretory-secretory products revealed by proteomics.
Vet Parasitol, 259.
pp. 25-34.
ISSN 1873-2550
https://doi.org/10.1016/j.vetpar.2018.06.015
SGUL Authors: Cooper, Philip John
![[img]](https://openaccess.sgul.ac.uk/style/images/fileicons/application_vnd.openxmlformats-officedocument.wordprocessingml.document.png) |
Microsoft Word (.docx)
Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (228kB) |
|
|
Microsoft Word (.docx) (Supplementary tables)
Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (111kB) |
|
|
PDF (Figure)
Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (348kB) | Preview |
|
|
PDF (Graphical abstract)
Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (422kB) | Preview |
Abstract
Toxocariasis is a widespread helminth infection of dogs and cats, caused by Toxocara canis and Toxocara cati larvae, respectively. Toxocara spp. can cause zoonotic infections in humans by invading tissues and organs causing pathology. Toxocara spp. larvae release excretory-secretory molecules (TES) into the body of their host that are fundamental to the host-parasite interaction and could be used as targets for novel diagnostics and vaccines. In the present study, we identified 646 T. canis proteins from TES and larval extract using 1D-SDS PAGE followed by mass spectrometry. A wide range of proteins was identified that may play a role both in the induction of the host immune response and host pathology, and in parasite metabolism and survival. Among these proteins there are potential candidates for novel diagnostics and vaccines for dogs and cats toxocariases.
| Item Type: | Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Additional Information: | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | ||||||||
| Keywords: | Excretory/secretory proteins, Larvae, Proteomics, Toxocara canis, Toxocariasis, Excretory/secretory proteins, Larvae, Proteomics, Toxocara canis, Toxocariasis, Mycology & Parasitology, 0605 Microbiology, 0704 Fisheries Sciences, 0707 Veterinary Sciences | ||||||||
| SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) | ||||||||
| Journal or Publication Title: | Vet Parasitol | ||||||||
| ISSN: | 1873-2550 | ||||||||
| Language: | eng | ||||||||
| Dates: |
|
||||||||
| Publisher License: | Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 | ||||||||
| Projects: |
|
||||||||
| PubMed ID: | 30056980 | ||||||||
 |
Go to PubMed abstract | ||||||||
| URI: | https://openaccess.sgul.ac.uk/id/eprint/110113 | ||||||||
| Publisher's version: | https://doi.org/10.1016/j.vetpar.2018.06.015 |
Statistics
Actions (login required)
 |
Edit Item |