Update to: Study Pre-protocol for “BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study”

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Williams, TC; Cunningham, S; Drysdale, SB; Groves, H; Iskander, D; Liu, X; Lyttle, MD; Marlow, R; Maxwell-Hodkinson, A; Mpamhanga, CD; et al. Williams, TC; Cunningham, S; Drysdale, SB; Groves, H; Iskander, D; Liu, X; Lyttle, MD; Marlow, R; Maxwell-Hodkinson, A; Mpamhanga, CD; O'Hagan, S; Sinha, I; Swann, OV; Waterfield, T; Roland, D (2024) Update to: Study Pre-protocol for “BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study”. Wellcome Open Research, 6. p. 120. ISSN 2398-502X https://doi.org/10.12688/wellcomeopenres.16778.4
SGUL Authors: Drysdale, Simon Bruce

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Official URL: https://doi.org/10.12688/wellcomeopenres.16778.4

Abstract

<ns3:p>Background In 2021 we launched the BronchStart study, which collected information on 17,899 presentations in children with serious respiratory tract infections following the release of lockdown restrictions. Our study informed the Joint Committee on Vaccination and Immunisation’s decision to recommend the introduction maternal respiratory syncytial virus (RSV) vaccination, which was introduced in the United Kingdom in August/September 2024. Study question We modified our original protocol to conduct a United Kingdom-wide assessment of maternal vaccination against RSV. Methods and likely impact We will conduct a multi-centre study, utilising the PERUKI network used in the original BronchStart study, to assess the effectiveness of maternal vaccination using a test-negative study design. We will gather detailed clinical information on children admitted with bronchiolitis in the post-RSV vaccination era, and understand possible reasons for incomplete vaccine uptake.</ns3:p>

Item Type:

Article

Additional Information:

Copyright: © 2024 Williams TC et al. This is an open access work distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords:

Bronchiolitis, COVID-19, Children, Infants, Palivizumab, Respiratory Syncytial Virus

SGUL Research Institute / Research Centre:

Academic Structure > Infection and Immunity Research Institute (INII)

Journal or Publication Title:

Wellcome Open Research

ISSN:

2398-502X

Language:

Media of Output:

Electronic-eCollection

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