Davidson, HC;
Griffin, A-E;
Symes, L;
Laing, KG;
Witney, AA;
Gould, K;
Allebone-Salt, P;
Abadioru, O;
Goldenberg, SD;
Otter, JA;
et al.
Davidson, HC; Griffin, A-E; Symes, L; Laing, KG; Witney, AA; Gould, K; Allebone-Salt, P; Abadioru, O; Goldenberg, SD; Otter, JA; Wake, R; Bicanic, T
(2025)
Detection of Candidozyma (formerly Candida) auris from ward wastewater during an outbreak using culture and molecular methods.
Journal of Hospital Infection.
S0195-6701(25)00345.
ISSN 0195-6701
https://doi.org/10.1016/j.jhin.2025.10.024
SGUL Authors: Davidson, Harriet Claire
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Abstract
We report the first detection of Candidozyma (formerly Candida) auris from ward wastewater using culture (sensitivity for detection of ≥1 C. auris patient on ward: 75%) and PCR (sensitivity: 100%). This proof-of-principle study was undertaken using matched clinical and ward wastewater samples during a large UK hospital outbreak. Sequenced wastewater and patient isolates were genetically identical (<10 SNPs different). Screening ward wastewater may be a cost-effective alternative to clinical (individual patient) screening in low prevalence settings.
| Item Type: | Article | |||||||||
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| Additional Information: | © 2025 The Authors. Published by Elsevier Ltd on behalf of The Healthcare Infection Society. Under a Creative Commons license (http://creativecommons.org/licenses/by/4.0/) | |||||||||
| Keywords: | Candida auris, Candidozyma auris, HCAI, outbreak, surveillance, ward wastewater, wastewater | |||||||||
| SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) | |||||||||
| Journal or Publication Title: | Journal of Hospital Infection | |||||||||
| ISSN: | 0195-6701 | |||||||||
| Language: | en | |||||||||
| Media of Output: | Print-Electronic | |||||||||
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| Publisher License: | Creative Commons: Attribution 4.0 | |||||||||
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| PubMed ID: | 41197875 | |||||||||
| Dates: |
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| URI: | https://openaccess.sgul.ac.uk/id/eprint/118060 | |||||||||
| Publisher's version: | https://doi.org/10.1016/j.jhin.2025.10.024 |
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