Daniel, O; Srikanth, S; Clarke, P; Le Doare, K; Heath, PT; Jones, CE; Scorrer, T; Snape, M; Calvert, A
(2025)
Pertussis antibody responses in infants born to mothers vaccinated at different time points in pregnancy.
Vaccine, 62.
p. 127481.
ISSN 0264-410X
https://doi.org/10.1016/j.vaccine.2025.127481
SGUL Authors: Daniel, Olwenn Elea
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Abstract
The optimal timing of pertussis vaccination in pregnancy is debated, especially to maximise antibody concentrations in infants born preterm. This study investigated immunoglobulin G (IgG) in preterm infants at 5 and 12 months, whose mothers had received a pertussis-containing vaccine at different gestations or were unvaccinated. Results show that vaccination in the early-mid second trimester may result in increased FHA specific IgG concentrations in preterm infants at 5 and 12 months. The BEAR PAW study used residual serum samples from the BEAR Men B study (Babies born Early Antibody Response to Men B vaccination (NCT03125616)).
| Item Type: | Article |
|---|---|
| Additional Information: | © 2025 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
| SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) |
| Journal or Publication Title: | Vaccine |
| ISSN: | 0264-410X |
| Language: | en |
| Publisher License: | Creative Commons: Attribution 4.0 |
| URI: | https://openaccess.sgul.ac.uk/id/eprint/117709 |
| Publisher's version: | https://doi.org/10.1016/j.vaccine.2025.127481 |
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