Hanquet, G;
Krizova, P;
Dalby, T;
Ladhani, SN;
Nuorti, JP;
Danis, K;
Mereckiene, J;
Knol, MJ;
Winje, BA;
Ciruela, P;
et al.
Hanquet, G; Krizova, P; Dalby, T; Ladhani, SN; Nuorti, JP; Danis, K; Mereckiene, J; Knol, MJ; Winje, BA; Ciruela, P; de Miguel, S; Portillo, ME; MacDonald, L; Morfeldt, E; Kozakova, J; Valentiner-Branth, P; Fry, NK; Rinta-Kokko, H; Varon, E; Corcoran, M; van der Ende, A; Vestrheim, DF; Munoz-Almagro, C; Sanz, J-C; Castilla, J; Smith, A; Henriques-Normark, B; Colzani, E; Pastore-Celentano, L; Savulescu, C; SpIDnet group1
(2022)
Serotype Replacement after Introduction of 10-Valent and 13-Valent Pneumococcal Conjugate Vaccines in 10 Countries, Europe.
Emerg Infect Dis, 28 (1).
pp. 137-138.
ISSN 1080-6040
https://doi.org/10.3201/eid2801.210734
SGUL Authors: Ladhani, Shamez Nizarali
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Abstract
We evaluated invasive pneumococcal disease (IPD) during 8 years of infant pneumococcal conjugate vaccine (PCV) programs using 10-valent (PCV10) and 13-valent (PCV13) vaccines in 10 countries in Europe. IPD incidence declined during 2011-2014 but increased during 2015-2018 in all age groups. From the 7-valent PCV period to 2018, IPD incidence declined by 42% in children <5 years of age, 32% in persons 5-64 years of age, and 7% in persons >65 years of age; non-PCV13 serotype incidence increased by 111%, 63%, and 84%, respectively, for these groups. Trends were similar in countries using PCV13 or PCV10, despite different serotype distribution. In 2018, serotypes in the 15-valent and 20-valent PCVs represented one third of cases in children <5 years of age and two thirds of cases in persons >65 years of age. Non-PCV13 serotype increases reduced the overall effect of childhood PCV10/PCV13 programs on IPD. New vaccines providing broader serotype protection are needed.
| Item Type: | Article | |||||||||
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| Additional Information: | Hanquet, G., Krizova, P., Dalby, T., Ladhani, S. N., Nuorti, J., Danis, K....Savulescu, C. (2022). Serotype Replacement after Introduction of 10-Valent and 13-Valent Pneumococcal Conjugate Vaccines in 10 Countries, Europe. Emerging Infectious Diseases, 28(1), 137-138. https://doi.org/10.3201/eid2801.210734. | |||||||||
| Keywords: | 10-valent pneumococcal vaccine, 13-valent pneumococcal vaccine, 15-valent pneumococcal vaccine, 20-valent pneumococcal vaccine, SpIDnet Multicenter Study, Streptococcus pneumoniae, bacteria, invasive pneumococcal disease, pneumococcal infections, respiratory infections, serotype, Adolescent, Adult, Child, Child, Preschool, Europe, Humans, Infant, Middle Aged, Pneumococcal Infections, Pneumococcal Vaccines, Serogroup, Streptococcus pneumoniae, Vaccines, Conjugate, Young Adult | |||||||||
| SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) | |||||||||
| Journal or Publication Title: | Emerg Infect Dis | |||||||||
| ISSN: | 1080-6040 | |||||||||
| Language: | eng | |||||||||
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| Publisher License: | Creative Commons: Attribution 4.0 | |||||||||
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| URI: | https://openaccess.sgul.ac.uk/id/eprint/117584 | |||||||||
| Publisher's version: | https://doi.org/10.3201/eid2801.210734 |
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