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Increased reports of severe myocarditis associated with enterovirus infection in neonates, United Kingdom, 27 June 2022 to 26 April 2023.

Singanayagam, A; Moore, C; Froude, S; Celma, C; Stowe, J; Hani, E; Ng, KF; Muir, P; Roderick, M; Cottrell, S; et al. Singanayagam, A; Moore, C; Froude, S; Celma, C; Stowe, J; Hani, E; Ng, KF; Muir, P; Roderick, M; Cottrell, S; Bibby, DF; Vipond, B; Gillett, S; Davis, PJ; Gibb, J; Barry, M; Harris, P; Rowley, F; Song, J; Shankar, AG; McMichael, D; Cohen, JM; Manian, A; Harvey, C; Primrose, LS; Wilson, S; Bradley, DT; Paranthaman, K; Beard, S; Zambon, M; Ramsay, M; Saliba, V; Ladhani, S; Williams, C (2023) Increased reports of severe myocarditis associated with enterovirus infection in neonates, United Kingdom, 27 June 2022 to 26 April 2023. Euro Surveill, 28 (39). ISSN 1025-496X https://doi.org/10.2807/1560-7917.ES.2023.28.39.2300313
SGUL Authors: Ladhani, Shamez Nizarali

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Abstract

Enteroviruses are a common cause of seasonal childhood infections. The vast majority of enterovirus infections are mild and self-limiting, although neonates can sometimes develop severe disease. Myocarditis is a rare complication of enterovirus infection. Between June 2022 and April 2023, twenty cases of severe neonatal enteroviral myocarditis caused by coxsackie B viruses were reported in the United Kingdom. Sixteen required critical care support and two died. Enterovirus PCR on whole blood was the most sensitive diagnostic test. We describe the initial public health investigation into this cluster and aim to raise awareness among paediatricians, laboratories and public health specialists.

Item Type: Article
Additional Information: This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence and indicate if changes were made. Any supplementary material referenced in the article can be found in the online version. This article is copyright of the authors or their affiliated institutions, 2023.
Keywords: coxsackie, enterovirus, myocarditis, neonatal infection, Infant, Newborn, Humans, Child, Myocarditis, Enterovirus Infections, Enterovirus, Enterovirus B, Human, Public Health
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Euro Surveill
ISSN: 1025-496X
Language: eng
Media of Output: Print
Related URLs:
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
NIHR201395National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
URI: https://openaccess.sgul.ac.uk/id/eprint/117549
Publisher's version: https://doi.org/10.2807/1560-7917.ES.2023.28.39.2300313

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