Jeffery-Smith, A;
Iyanger, N;
Williams, SV;
Chow, JY;
Aiano, F;
Hoschler, K;
Lackenby, A;
Ellis, J;
Platt, S;
Miah, S;
et al.
Jeffery-Smith, A; Iyanger, N; Williams, SV; Chow, JY; Aiano, F; Hoschler, K; Lackenby, A; Ellis, J; Platt, S; Miah, S; Brown, K; Amirthalingam, G; Patel, M; Ramsay, ME; Gopal, R; Charlett, A; Ladhani, SN; Zambon, M
(2021)
Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020.
Euro Surveill, 26 (5).
ISSN 1560-7917
https://doi.org/10.2807/1560-7917.ES.2021.26.5.2100092
SGUL Authors: Ladhani, Shamez Nizarali
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Abstract
Two London care homes experienced a second COVID-19 outbreak, with 29/209 (13.9%) SARS-CoV-2 RT-PCR-positive cases (16/103 residents, 13/106 staff). In those with prior SARS-CoV-2 exposure, 1/88 (1.1%) individuals (antibody positive: 87; RT-PCR-positive: 1) became PCR-positive compared with 22/73 (30.1%) with confirmed seronegative status. After four months protection offered by prior infection against re-infection was 96.2% (95% confidence interval (CI): 72.7-99.5%) using risk ratios from comparison of proportions and 96.1% (95% CI: 78.8-99.3%) using a penalised logistic regression model.
| Item Type: | Article |
|---|---|
| Additional Information: | This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence and indicate if changes were made. Any supplementary material referenced in the article can be found in the online version. This article is copyright of the authors or their affiliated institutions, 2021 |
| Keywords: | COVID-19 outbreak, care homes, Adult, Aged, Aged, 80 and over, Antibodies, Viral, COVID-19, COVID-19 Serological Testing, Disease Outbreaks, Female, Humans, London, Male, Middle Aged, Nursing Homes, Pandemics, Reinfection, Reverse Transcriptase Polymerase Chain Reaction, SARS-CoV-2, Whole Genome Sequencing, Humans, Antibodies, Viral, Reverse Transcriptase Polymerase Chain Reaction, Disease Outbreaks, Adult, Aged, Aged, 80 and over, Middle Aged, Nursing Homes, London, Female, Male, Pandemics, Whole Genome Sequencing, COVID-19, SARS-CoV-2, COVID-19 Serological Testing, Reinfection, 0605 Microbiology, 1117 Public Health and Health Services, 1199 Other Medical and Health Sciences |
| SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) |
| Journal or Publication Title: | Euro Surveill |
| ISSN: | 1560-7917 |
| Language: | eng |
| Publisher License: | Creative Commons: Attribution 4.0 |
| PubMed ID: | 33541486 |
| Web of Science ID: | WOS:000615718500002 |
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Go to PubMed abstract |
| URI: | https://openaccess.sgul.ac.uk/id/eprint/117295 |
| Publisher's version: | https://doi.org/10.2807/1560-7917.ES.2021.26.5.2100092 |
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