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Exploring Health-Related Quality of Life (HRQOL) among patients with HIV-associated TB in Khayelitsha, South Africa.

Hickman, J-H; Swartz, A; Sicwebu, N; Stek, C; Masimini, N; Nöstlinger, C (2024) Exploring Health-Related Quality of Life (HRQOL) among patients with HIV-associated TB in Khayelitsha, South Africa. PLoS One, 19 (11). e0275554. ISSN 1932-6203 https://doi.org/10.1371/journal.pone.0275554
SGUL Authors: Swartz, Alison

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Abstract

BACKGROUND: Health-related quality of life (HRQOL) is an important and frequently used patient-reported outcome in health research. However, little qualitative research exists in this field in South Africa. This study was set in Khayelitsha, one of the largest informal settlements in South Africa, where the burden of HIV and tuberculosis (TB) co-infection are amongst the highest in the world and significantly affect HRQOL. OBJECTIVE: To explore the experience of HRQOL among patients living with HIV-associated TB. METHODS: We conducted sixteen interviews with male (n = 10) and female (n = 6) adult participants (ages 24-56; median age 35) to explore their HRQOL living with HIV-associated TB, related treatment and how this impacted on life domains they considered relevant for HRQOL. We used thematic analysis to analyse data, using both an inductive and deductive analysis using an interpretive phenomenological approach (IPA). RESULTS: Experiences of HRQOL were identified along the predominantly emerging themes of physical, social, and mental aspects of HRQOL. Identified sub-themes included well-being, loss of strength, and self-care for the physical domain; usual activities and stigma for the social domain; concerns and coping for the mental domain. The findings illustrate that HRQOL domains are interconnected through social experience. The social experience of HRQOL was identified as the common denominator connecting all domains, around which HRQOL revolved for these participants. CONCLUSION: HRQOL is experienced socially. The interpersonal connections patients have with significant others present as key to high HRQOL among patients living with HIV-associated TB. This study adds to the existing literature of HRQOL and examines HRQOL using IPA which may help to inform future interventions to improve HRQOL among HIV/TB patients.

Item Type: Article
Additional Information: Copyright: © 2024 Hickman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Humans, Quality of Life, Male, Female, Adult, South Africa, HIV Infections, Middle Aged, Tuberculosis, Young Adult, Coinfection, Humans, Tuberculosis, HIV Infections, Quality of Life, Adult, Middle Aged, South Africa, Female, Male, Young Adult, Coinfection, General Science & Technology
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE )
Journal or Publication Title: PLoS One
ISSN: 1932-6203
Language: eng
Dates:
DateEvent
4 November 2024Published
27 August 2024Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
SP.2011.41304.074European and Developing Countries Clinical Trials Partnershiphttp://dx.doi.org/10.13039/501100001713
UNSPECIFIEDSouth African Government Department of Science and TechnologyUNSPECIFIED
098316Wellcome Trusthttp://dx.doi.org/10.13039/100004440
084323Wellcome Trusthttp://dx.doi.org/10.13039/100004440
104803Wellcome Trusthttp://dx.doi.org/10.13039/100004440
203135Wellcome Trusthttp://dx.doi.org/10.13039/100004440
UNSPECIFIEDInstitute of Tropical MedicineUNSPECIFIED
D43 TW011308National Institute of Mental Healthhttp://dx.doi.org/10.13039/100000025
PubMed ID: 39495745
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/116942
Publisher's version: https://doi.org/10.1371/journal.pone.0275554

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