Lubin, R;
Patel, AA;
Mackerodt, J;
Zhang, Y;
Gvili, R;
Mulder, K;
Dutertre, C-A;
Jalali, P;
Glanville, JRW;
Hazan, I;
et al.
Lubin, R; Patel, AA; Mackerodt, J; Zhang, Y; Gvili, R; Mulder, K; Dutertre, C-A; Jalali, P; Glanville, JRW; Hazan, I; Sridharan, N; Rivkin, G; Akarca, A; Marafioti, T; Gilroy, DW; Kandel, L; Mildner, A; Wilensky, A; Asquith, B; Ginhoux, F; Macallan, D; Yona, S
(2024)
The lifespan and kinetics of human dendritic cell subsets and their precursors in health and inflammation.
J Exp Med, 221 (11).
e20220867.
ISSN 1540-9538
https://doi.org/10.1084/jem.20220867
SGUL Authors: Macallan, Derek Clive
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Abstract
Dendritic cells (DC) are specialized mononuclear phagocytes that link innate and adaptive immunity. They comprise two principal subsets: plasmacytoid DC (pDC) and conventional DC (cDC). Understanding the generation, differentiation, and migration of cDC is critical for immune homeostasis. Through human in vivo deuterium-glucose labeling, we observed the rapid appearance of AXL+ Siglec6+ DC (ASDC) in the bloodstream. ASDC circulate for ∼2.16 days, while cDC1 and DC2 circulate for ∼1.32 and ∼2.20 days, respectively, upon release from the bone marrow. Interestingly, DC3, a cDC subset that shares several similarities with monocytes, exhibits a labeling profile closely resembling that of DC2. In a human in vivo model of cutaneous inflammation, ASDC were recruited to the inflammatory site, displaying a distinctive effector signature. Taken together, these results quantify the ephemeral circulating lifespan of human cDC and propose functions of cDC and their precursors that are rapidly recruited to sites of inflammation.
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| Additional Information: | © 2024 Lubin et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). | |||||||||||||||||||||||||||||||||
| Keywords: | Humans, Dendritic Cells, Inflammation, Kinetics, Cell Differentiation, Male, Axl Receptor Tyrosine Kinase, Female, Adult, Dendritic Cells, Humans, Inflammation, Cell Differentiation, Kinetics, Adult, Female, Male, Axl Receptor Tyrosine Kinase, 11 Medical and Health Sciences, Immunology | |||||||||||||||||||||||||||||||||
| SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) TACRI |
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| Journal or Publication Title: | J Exp Med | |||||||||||||||||||||||||||||||||
| ISSN: | 1540-9538 | |||||||||||||||||||||||||||||||||
| Language: | eng | |||||||||||||||||||||||||||||||||
| Dates: |
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| Publisher License: | Publisher's own licence | |||||||||||||||||||||||||||||||||
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| PubMed ID: | 39417994 | |||||||||||||||||||||||||||||||||
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| URI: | https://openaccess.sgul.ac.uk/id/eprint/116907 | |||||||||||||||||||||||||||||||||
| Publisher's version: | https://doi.org/10.1084/jem.20220867 |
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