Targeting Canonical Wnt-signaling Through GSK-3β in Arrhythmogenic Cardiomyopathy: Conservative or Progressive?

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Low, BSH; Asimaki, A (2024) Targeting Canonical Wnt-signaling Through GSK-3β in Arrhythmogenic Cardiomyopathy: Conservative or Progressive? JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH. ISSN 1937-5387 https://doi.org/10.1007/s12265-024-10567-x
SGUL Authors: Asimaki, Angeliki

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Official URL: https://doi.org/10.1007/s12265-024-10567-x

Abstract

Arrhythmogenic cardiomyopathy is a primary myocardial disease and a major cause of sudden death in all populations of the world. Canonical Wnt signalling is a critical pathway controlling numerous processes including cellular differentiation, hypertrophy and development. GSK3β is a ubiquitous serine/threonine kinase, which acts downstream of Wnt to promote protein ubiquitination and proteasomal degradation. Several studies now suggest that inhibiting GSK3β can prevent and reverse key pathognomonic features of ACM in a range of experimental models. However, varying concerns are reported throughout the literature including the risk of paradoxical arrhythmias, cancer and off-target effects in upstream or downstream pathways.

Item Type:

Article

Additional Information:

© The Author(s) 2024 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Keywords:

Canonical Wnt-signaling, Glycogen synthase kinase 3 beta, Hippo, Arrhythmogenic cardiomyopathy, SB216763, CHIR99021, Tideglusib

Journal or Publication Title:

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH

ISSN:

1937-5387

Dates: