Scerrati, A;
Gozzi, A;
Cavallo, MA;
Mantovani, G;
Antenucci, P;
Angelini, C;
Capone, JG;
De Bonis, P;
Morgante, F;
Rispoli, V;
et al.
Scerrati, A; Gozzi, A; Cavallo, MA; Mantovani, G; Antenucci, P; Angelini, C; Capone, JG; De Bonis, P; Morgante, F; Rispoli, V; Sensi, M
(2024)
Thalamic ventral-Oralis complex/rostral zona incerta deep brain stimulation for midline tremor.
J Neurol.
ISSN 1432-1459
https://doi.org/10.1007/s00415-024-12619-3
SGUL Authors: Morgante, Francesca
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Abstract
BACKGROUND: Midline Tremor is defined as an isolated or combined tremor that affects the neck, trunk, jaw, tongue, and/or voice and could be part of Essential Tremor (ET), or dystonic tremor. The clinical efficacy of deep brain stimulation for Midline Tremor has been rarely reported. The Ventral Intermediate Nucleus and Globus Pallidus Internus are the preferred targets, but with variable outcomes. Thalamic Ventral-Oralis (VO) complex and Zona Incerta (ZI) are emerging targets for tremor control in various etiologies. OBJECTIVE: To report on neuroradiological, neurophysiological targeting and long-term efficacy of thalamic Ventral-Oralis complex and Zona Incerta deep brain stimulation in Midline Tremor. METHODS: Three patients (two males and one female) with Midline Tremor in dystonic syndromes were recruited for this open-label study. Clinical, surgical, neurophysiological intraoperative testing and long-term follow-up data are reported. RESULTS: Intraoperative testing and reconstruction of volume of tissue activated confirmed the position of the electrodes in the area stimulated between the thalamic Ventral-Oralis complex and Zona Incerta in all patients. All three patients showed optimal control of both tremor and dystonic features at short-term (6 months) and long-term follow-up (up to 6 years). No adverse events occurred. CONCLUSION: In the syndromes of Midline Tremor of various origins, the best target for DBS might be difficult to identify. Our results showed that thalamic Ventral-Oralis complex/Zona Incerta may be a viable and safe option even in specific forms of tremor with axial distribution.
Item Type: | Article | ||||||
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Additional Information: | Further supplementary information available at: https://doi.org/10.1007/s00415-024-12619-3 © The Author(s) 2024 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | ||||||
Keywords: | DBS, Dystonia, Midline tremor, Thalamus, Ventral-Oralis complex, Zona Incerta, Midline tremor, Dystonia, DBS, Ventral-Oralis complex, Zona Incerta, Thalamus, 1103 Clinical Sciences, 1109 Neurosciences, Neurology & Neurosurgery | ||||||
SGUL Research Institute / Research Centre: | Academic Structure > REF 2021 user group | ||||||
Journal or Publication Title: | J Neurol | ||||||
ISSN: | 1432-1459 | ||||||
Language: | eng | ||||||
Dates: |
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Publisher License: | Creative Commons: Attribution 4.0 | ||||||
PubMed ID: | 39126514 | ||||||
Web of Science ID: | WOS:001287971500001 | ||||||
Go to PubMed abstract | |||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/116784 | ||||||
Publisher's version: | https://doi.org/10.1007/s00415-024-12619-3 |
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