von Mollendorf, C;
Mungun, T;
Ulziibayar, M;
Skoko, P;
Boelsen, L;
Nguyen, C;
Batsaikhan, P;
Suuri, B;
Luvsantseren, D;
Narangerel, D;
et al.
von Mollendorf, C; Mungun, T; Ulziibayar, M; Skoko, P; Boelsen, L; Nguyen, C; Batsaikhan, P; Suuri, B; Luvsantseren, D; Narangerel, D; Tsolmon, B; Demberelsuren, S; Ortika, BD; Pell, CL; Wee-Hee, A; Nation, ML; Hinds, J; Dunne, EM; Mulholland, EK; Satzke, C
(2024)
Effect of pneumococcal conjugate vaccine six years post-introduction on pneumococcal carriage in Ulaanbaatar, Mongolia.
Nat Commun, 15 (1).
p. 6577.
ISSN 2041-1723
https://doi.org/10.1038/s41467-024-50944-3
SGUL Authors: Hinds, Jason
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Abstract
Limited data from Asia are available on long-term effects of pneumococcal conjugate vaccine introduction on pneumococcal carriage. Here we assess the impact of 13-valent pneumococcal conjugate vaccine (PCV13) introduction on nasopharyngeal pneumococcal carriage prevalence, density and antimicrobial resistance. Cross-sectional carriage surveys were conducted pre-PCV13 (2015) and post-PCV13 introduction (2017 and 2022). Pneumococci were detected and quantified by real-time PCR from nasopharyngeal swabs. DNA microarray was used for molecular serotyping and to infer genetic lineage (Global Pneumococcal Sequence Cluster). The study included 1461 infants (5-8 weeks old) and 1489 toddlers (12-23 months old) enrolled from family health clinics. We show a reduction in PCV13 serotype carriage (with non-PCV13 serotype replacement) and a reduction in the proportion of samples containing resistance genes in toddlers six years post-PCV13 introduction. We observed an increase in pneumococcal nasopharyngeal density. Serotype 15 A, the most prevalent non-vaccine-serotype in 2022, was comprised predominantly of GPSC904;9. Reductions in PCV13 serotype carriage will likely result in pneumococcal disease reduction. It is important for ongoing surveillance to monitor serotype changes to potentially inform new vaccine development.
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Additional Information: | Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. © The Author(s) 2024 | |||||||||||||||
Keywords: | Pneumococcal Vaccines, Humans, Streptococcus pneumoniae, Infant, Pneumococcal Infections, Nasopharynx, Carrier State, Mongolia, Cross-Sectional Studies, Vaccines, Conjugate, Female, Male, Serogroup, Prevalence, Serotyping | |||||||||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) Academic Structure > REF 2021 user group |
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Journal or Publication Title: | Nat Commun | |||||||||||||||
ISSN: | 2041-1723 | |||||||||||||||
Language: | eng | |||||||||||||||
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Publisher License: | Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 | |||||||||||||||
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PubMed ID: | 39097620 | |||||||||||||||
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URI: | https://openaccess.sgul.ac.uk/id/eprint/116747 | |||||||||||||||
Publisher's version: | https://doi.org/10.1038/s41467-024-50944-3 |
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