Julovi, SM; Trinh, K; Robertson, H; Xu, C; Minhas, N; Viswanathan, S; Patrick, E; Horowitz, JD; Meijles, DN; Rogers, NM
(2024)
Thrombospondin-1 Drives Cardiac Remodeling in Chronic Kidney Disease.
JACC Basic Transl Sci, 9 (5).
pp. 607-627.
ISSN 2452-302X
https://doi.org/10.1016/j.jacbts.2024.01.010
SGUL Authors: Meijles, Daniel Nathan
Abstract
Patients with chronic kidney disease (CKD) face a high risk of cardiovascular disease. Previous studies reported that endogenous thrombospondin 1 (TSP1) involves right ventricular remodeling and dysfunction. Here we show that a murine model of CKD increased myocardial TSP1 expression and produced left ventricular hypertrophy, fibrosis, and dysfunction. TSP1 knockout mice were protected from these features. In vitro, indoxyl sulfate is driving deleterious changes in cardiomyocyte through the TSP1. In patients with CKD, TSP1 and aryl hydrocarbon receptor were both differentially expressed in the myocardium. Our findings summon large clinical studies to confirm the translational role of TSP1 in patients with CKD.
Item Type: |
Article
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Additional Information: |
© 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: |
aryl hydrocarbon receptor, cardiac fibrosis, chronic kidney disease, left ventricular hypertrophy, thrombospondin 1, aryl hydrocarbon receptor, cardiac fi brosis, chronic kidney disease, left ventricular hypertrophy, thrombospondin 1, 1102 Cardiorespiratory Medicine and Haematology, 1103 Clinical Sciences |
SGUL Research Institute / Research Centre: |
Academic Structure > REF 2021 user group |
Journal or Publication Title: |
JACC Basic Transl Sci |
ISSN: |
2452-302X |
Language: |
eng |
Dates: |
Date | Event |
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27 May 2024 | Published | 27 March 2024 | Published Online | 29 January 2024 | Accepted |
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Publisher License: |
Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 |
Projects: |
Project ID | Funder | Funder ID |
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GNT2007991 | National Health and Medical Research Council | http://dx.doi.org/10.13039/501100000925 | 106035 | National Heart Foundation | UNSPECIFIED | UNSPECIFIED | Westmead Medical Research Foundation | UNSPECIFIED |
|
PubMed ID: |
38984053 |
Web of Science ID: |
WOS:001247045200001 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/116731 |
Publisher's version: |
https://doi.org/10.1016/j.jacbts.2024.01.010 |
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