Morrissey, CO;
Kim, HY;
Garnham, K;
Dao, A;
Chakrabarti, A;
Perfect, JR;
Alastruey-Izquierdo, A;
Harrison, TS;
Bongomin, F;
Galas, M;
et al.
Morrissey, CO; Kim, HY; Garnham, K; Dao, A; Chakrabarti, A; Perfect, JR; Alastruey-Izquierdo, A; Harrison, TS; Bongomin, F; Galas, M; Siswanto, S; Dagne, DA; Roitberg, F; Gigante, V; Sati, H; Alffenaar, J-W; Beardsley, J
(2024)
Mucorales: A systematic review to inform the World Health Organization priority list of fungal pathogens.
Med Mycol, 62 (6).
ISSN 1460-2709
https://doi.org/10.1093/mmy/myad130
SGUL Authors: Harrison, Thomas Stephen
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Abstract
The World Health Organization, in response to the growing burden of fungal disease, established a process to develop a fungal priority pathogens list (FPPL). This systematic review aimed to evaluate the epidemiology and impact of invasive fungal disease due to Mucorales. PubMed and Web of Science were searched to identify studies published between January 1, 2011 and February 23, 2021. Studies reporting on mortality, inpatient care, complications and sequelae, antifungal susceptibility, risk factors, preventability, annual incidence, global distribution, and emergence during the study time frames were selected. Overall, 24 studies were included. Mortality rates of up to 80% were reported. Antifungal susceptibility varied across agents and species, with the minimum inhibitory concentrations lowest for amphotericin B and posaconazole. Diabetes mellitus was a common risk factor, detected in 65%-85% of patients with mucormycosis, particularly in those with rhino-orbital disease (86.9%). Break-through infection was detected in 13.6%-100% on azole or echinocandin antifungal prophylaxis. The reported prevalence rates were variable, with some studies reporting stable rates in the USA of 0.094-0.117/10 000 discharges between 2011 and 2014, whereas others reported an increase in Iran from 16.8% to 24% between 2011 and 2015. Carefully designed global surveillance studies, linking laboratory and clinical data, are required to develop clinical breakpoints to guide antifungal therapy and determine accurate estimates of complications and sequelae, annual incidence, trends, and global distribution. These data will provide robust estimates of disease burden to refine interventions and better inform future FPPL.
Item Type: | Article | |||||||||
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Additional Information: | © The Author(s) 2023. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com | |||||||||
Keywords: | Mucorales, epidemiology, incidence, invasive fungal disease, mortality, mucormycosis, risk factors, susceptibility, Humans, Mucorales, Antifungal Agents, Mucormycosis, World Health Organization, Risk Factors, Invasive Fungal Infections, Microbial Sensitivity Tests, Prevalence, Drug Resistance, Fungal, Incidence, Global Health, Humans, Mucorales, Mucormycosis, Antifungal Agents, Microbial Sensitivity Tests, Incidence, Prevalence, Risk Factors, Drug Resistance, Fungal, World Health Organization, Global Health, Invasive Fungal Infections, 1108 Medical Microbiology, Microbiology | |||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) Academic Structure > REF 2021 user group |
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Journal or Publication Title: | Med Mycol | |||||||||
ISSN: | 1460-2709 | |||||||||
Language: | eng | |||||||||
Dates: |
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Publisher License: | Creative Commons: Attribution-Noncommercial 4.0 | |||||||||
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PubMed ID: | 38935901 | |||||||||
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URI: | https://openaccess.sgul.ac.uk/id/eprint/116622 | |||||||||
Publisher's version: | https://doi.org/10.1093/mmy/myad130 |
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