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The utility of dynamic contrast-enhanced intranodal magnetic resonance lymphangiography (MRL) in the investigation of primary lymphatic anomalies.

Ratnam, LA; Mills, M; Wale, A; Howroyd, LR; Itkin, M; Howe, FA; Gordon, K; Mansour, S; Ostergaard, P; Mortimer, PS (2024) The utility of dynamic contrast-enhanced intranodal magnetic resonance lymphangiography (MRL) in the investigation of primary lymphatic anomalies. Clin Radiol, 79 (10). e1180-e1188. ISSN 1365-229X https://doi.org/10.1016/j.crad.2024.06.009
SGUL Authors: Arumugam Ratnam, Lakshmi Ostergaard, Pia Mills, Michael James Howe, Franklyn Arron Mansour, Sahar

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Abstract

AIM: The aim of this study was to describe the technique of DCMRL to identify central lymphatic abnormalities in patients with primary lymphatic anomalies and discuss utility of the findings. MATERIALS AND METHODS: Twenty-eight patients with primary lymphatic abnormalities underwent dynamic magnetic resonance imaging (MRI) following injection of gadolinium directly into inguinal lymph nodes at a tertiary lymphovascular referral center. RESULTS: Technical success was achieved in 23 patients (82.1%). Pathological imaging findings included obstructed, hypoplastic, or absent lymphatic channels with collateralization/rerouting or reflux of flow, lymphangiectasia, lymphatic pseudoaneurysms, and lymph leaks. Protocol modifications for improved imaging are highlighted including technical aspects of lymph node injection, image acquisition and MRI parameters. In two patients, imaging findings warranted embolization of the abnormal lymphatic channels with subsequent symptomatic improvement. CONCLUSION: DCMRL has been shown to be a safe, reproducible technique in patients with primary lymphatic anomalies enabling imaging of the central lymphatic system.

Item Type: Article
Additional Information: © 2024 The Authors. Published by Elsevier Ltd on behalf of The Royal College of Radiologists. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Humans, Female, Contrast Media, Male, Magnetic Resonance Imaging, Adult, Lymphatic Abnormalities, Child, Adolescent, Middle Aged, Lymphography, Child, Preschool, Young Adult, Lymph Nodes, Infant, Aged, Lymph Nodes, Humans, Lymphatic Abnormalities, Contrast Media, Magnetic Resonance Imaging, Lymphography, Adolescent, Adult, Aged, Middle Aged, Child, Child, Preschool, Infant, Female, Male, Young Adult, 1103 Clinical Sciences, Nuclear Medicine & Medical Imaging
SGUL Research Institute / Research Centre: Academic Structure > REF 2021 user group
TACRI
Journal or Publication Title: Clin Radiol
ISSN: 1365-229X
Language: eng
Dates:
DateEvent
5 September 2024Published
13 June 2002Published Online
1 June 2024Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
MR/P011543/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
RG/17/7/33217British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
PubMed ID: 39003166
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/116601
Publisher's version: https://doi.org/10.1016/j.crad.2024.06.009

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