Thulin, IVL; Myrmel, GMS; Jordalen, SMF; Collinson, P; Aakre, KM
(2023)
Point-of-care high-sensitivity troponin assays: advancements, clinical applications, and implementation considerations.
JOURNAL OF LABORATORY AND PRECISION MEDICINE, 8.
p. 20.
ISSN 2519-9005
https://doi.org/10.21037/jlpm-23-3
SGUL Authors: Collinson, Paul
Abstract
High-sensitivity cardiac troponin (hs-cTn) assays have changed the workflow in emergency departments allowing for rapid allocation of patients with high or low risk of non-ST elevation myocardial infarction. Recently, hs-cTn point-of-care testing (POCT) assays have become available. There are significant expectations that this technology will improve patient flow, reduce overcrowding in emergency departments and improve prehospital investigations for acute coronary syndrome. Measurements of hs-cTn by POCT may also have a role in other health care facilities where hs-cTn measurements are useful but currently unavailable or have long turn-around time and may provide backup instruments for central laboratory platforms in smaller laboratories. This review describes the currently available hs-cTn POCT assays and include an update on recently published clinical data. It outlines benefits of using POCT hs-cTn assays including the possibility of more efficient management of patients with symptoms suggestive of acute coronary syndrome. Additionally, we discuss alternative conditions and clinical and practical scenarios where these assays may become useful. Finally, it highlights the broad spectrum of issues that come along with the implementation of POCT, and suggest the scientific data and practical considerations that should be in place before hs-cTn POCT may be successfully implemented into the daily routine.
Item Type: |
Article
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Additional Information: |
This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/. |
Keywords: |
Point-of-care testing (POCT), high-sensitivity cardiac troponin (hs-cTn), cardiovascular biomarkers, acute coronary syndrome (ACS) |
Journal or Publication Title: |
JOURNAL OF LABORATORY AND PRECISION MEDICINE |
ISSN: |
2519-9005 |
Dates: |
Date | Event |
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30 July 2023 | Published | 25 July 2023 | Published Online | 13 July 2023 | Accepted |
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Publisher License: |
Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 |
Web of Science ID: |
WOS:001222054000001 |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/116556 |
Publisher's version: |
https://doi.org/10.21037/jlpm-23-3 |
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