Cucinotta, F; Swinnen, B; Makovac, E; Hirschbichler, S; Pereira, E; Little, S; Morgante, F; Ricciardi, L
(2024)
Short term cardiovascular symptoms improvement after deep brain stimulation in patients with Parkinson's disease: a systematic review.
J Neurol, 271 (7).
pp. 3764-3776.
ISSN 1432-1459
https://doi.org/10.1007/s00415-024-12459-1
SGUL Authors: Ricciardi, Lucia
Abstract
BACKGROUND: Autonomic dysfunction is common and disabling in Parkinson's disease (PD). The effects of deep brain stimulation (DBS) on the cardiovascular system in PD remain poorly understood. We aimed to assess the effect of DBS on cardiovascular symptoms and objective measures in PD patients. METHODS: We conducted a systematic literature search in PubMed/MEDLINE. RESULTS: 36 out of 472 studies were included, mostly involving DBS of the subthalamic nucleus, and to a lesser extent the globus pallidus pars interna and pedunculopontine nucleus. Seventeen studies evaluated the effect of DBS on patient-reported or clinician-rated cardiovascular symptoms, showing an improvement in the first year after surgery but not with longer-term follow-up. DBS has no clear direct effects on blood pressure during an orthostatic challenge (n = 10 studies). DBS has inconsistent effects on heart rate variability (n = 10 studies). CONCLUSION: Current evidence on the impact of DBS on cardiovascular functions in PD is inconclusive. DBS may offer short-term improvement of cardiovascular symptoms in PD, particularly orthostatic hypotension, which may be attributed to dopaminergic medication reduction after surgery. There is insufficient evidence to draw conclusions on the direct effect of DBS on blood pressure and heart rate variability.
Item Type: |
Article
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Additional Information: |
© The Author(s) 2024
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
Keywords: |
Cardiovascular functions, Deep brain stimulation, Heart rate variability, Parkinson’s disease, 1103 Clinical Sciences, 1109 Neurosciences, Neurology & Neurosurgery |
SGUL Research Institute / Research Centre: |
Academic Structure > REF 2021 user group |
Journal or Publication Title: |
J Neurol |
ISSN: |
1432-1459 |
Language: |
eng |
Dates: |
Date | Event |
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July 2024 | Published | 29 May 2024 | Published Online | 17 May 2024 | Accepted |
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Publisher License: |
Creative Commons: Attribution 4.0 |
PubMed ID: |
38809271 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/116549 |
Publisher's version: |
https://doi.org/10.1007/s00415-024-12459-1 |
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