Zong, X;
Kelishadi, R;
Kim, HS;
Schwandt, P;
Matsha, TE;
Mill, JG;
Caserta, CA;
Medeiros, CCM;
Kollias, A;
Whincup, PH;
et al.
Zong, X; Kelishadi, R; Kim, HS; Schwandt, P; Matsha, TE; Mill, JG; Caserta, CA; Medeiros, CCM; Kollias, A; Whincup, PH; Pacifico, L; López-Bermejo, A; Zhao, M; Zheng, M; Xi, B
(2024)
A proposed simplified definition of metabolic syndrome in children and adolescents: a global perspective.
BMC Med, 22 (1).
p. 190.
ISSN 1741-7015
https://doi.org/10.1186/s12916-024-03406-y
SGUL Authors: Whincup, Peter Hynes
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Abstract
Metabolic syndrome (MetS) is becoming prevalent in the pediatric population. The existing pediatric MetS definitions (e.g., the International Diabetes Federation (IDF) definition and the modified National Cholesterol Education Program (NCEP) definition) involve complex cut-offs, precluding fast risk assessment in clinical practice.We proposed a simplified definition for assessing MetS risk in youths aged 6-17 years, and compared its performance with two existing widely used pediatric definitions (the IDF definition, and the NCEP definition) in 10 pediatric populations from 9 countries globally (n = 19,426) using the receiver operating characteristic (ROC) curve analyses. In general, the total MetS prevalence of 6.2% based on the simplified definition was roughly halfway between that of 4.2% and 7.7% estimated from the IDF and NCEP definitions, respectively. The ROC curve analyses showed a good agreement between the simplified definition and two existing definitions: the total area under the curve (95% confidence interval) of the proposed simplified definition for identifying MetS risk achieved 0.91 (0.89-0.92) and 0.79 (0.78-0.81) when using the IDF or NCEP definition as the gold standard, respectively.The proposed simplified definition may be useful for pediatricians to quickly identify MetS risk and cardiometabolic risk factors (CMRFs) clustering in clinical practice, and allow direct comparison of pediatric MetS prevalence across different populations, facilitating consistent pediatric MetS risk monitoring and the development of evidence-based pediatric MetS prevention strategies globally.
Item Type: | Article | |||||||||
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Additional Information: | © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | |||||||||
Keywords: | Adolescent, Cardiovascular risk factors, Central obesity, Child, Hypertension, Metabolic syndrome, Waist-to-height ratio, Humans, Metabolic Syndrome, Adolescent, Child, Male, Female, Prevalence, ROC Curve, Global Health, Risk Assessment, Risk Factors, Humans, Prevalence, Risk Assessment, Risk Factors, ROC Curve, Adolescent, Child, Female, Male, Global Health, Metabolic Syndrome, Metabolic syndrome, Central obesity, Hypertension, Cardiovascular risk factors, Child, Waist-to-height ratio, Adolescent, 11 Medical and Health Sciences, General & Internal Medicine | |||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Population Health Research Institute (INPH) Academic Structure > REF 2021 user group |
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Journal or Publication Title: | BMC Med | |||||||||
ISSN: | 1741-7015 | |||||||||
Language: | eng | |||||||||
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Publisher License: | Creative Commons: Attribution 4.0 | |||||||||
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PubMed ID: | 38715060 | |||||||||
Web of Science ID: | WOS:001215645200004 | |||||||||
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URI: | https://openaccess.sgul.ac.uk/id/eprint/116529 | |||||||||
Publisher's version: | https://doi.org/10.1186/s12916-024-03406-y |
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