Gruson, D; Hammerer-Lercher, A; Collinson, P; Duff, C; Baum, H; Pulkki, K; Suvisaari, J; Stankovic, S; Laitinen, P; Bayes-Genis, A
(2024)
The multidimensional value of natriuretic peptides in heart failure, integrating laboratory and clinical aspects.
Crit Rev Clin Lab Sci, 61 (6).
pp. 458-472.
ISSN 1549-781X
https://doi.org/10.1080/10408363.2024.2319578
SGUL Authors: Collinson, Paul
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Abstract
Natriuretic peptides (NP) play an essential role in heart failure (HF) regulation, and their measurement has improved diagnostic and prognostic accuracy. Clinical symptoms and objective measurements, such as NP levels, should be included in the HF definition to render it more reliable and consistent among observers, hospitals, and healthcare systems. BNP and NT-proBNP are reasonable surrogates for cardiac disease, and their measurement is critical to early diagnosis and risk stratification of HF patients. NPs should be measured in all patients presenting with dyspnea or other symptoms suggestive of HF to facilitate early diagnosis and risk stratification. Both BNP and NT-proBNP are currently used for guided HF management and display comparable diagnostic and prognostic accuracy. Standardized cutoffs for each NP assay are essential for data comparison. The value of NP testing is recognized at various levels, including patient empowerment and education, analytical and operational issues, clinical HF management, and cost-effectiveness.
Item Type: | Article | ||||||
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Additional Information: | This is an Accepted Manuscript of an article published by Taylor & Francis in Critical Reviews in Clinical Laboratory Sciences on 25/04/2024, available at: https://doi.org/10.1080/10408363.2024.2319578. | ||||||
Keywords: | BNP, MR-proANP, NT-proBNP, Natriuretic peptides, acute heart failure, chronic heart failure, patient empowerment, Natriuretic peptides, MR-proANP, BNP, NT-proBNP, acute heart failure, chronic heart failure, patient empowerment, acute heart failure, BNP, chronic heart failure, MR-proANP, Natriuretic peptides, NT-proBNP, patient empowerment, 11 Medical and Health Sciences, Biochemistry & Molecular Biology | ||||||
Journal or Publication Title: | Crit Rev Clin Lab Sci | ||||||
ISSN: | 1549-781X | ||||||
Language: | eng | ||||||
Dates: |
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Publisher License: | Publisher's own licence | ||||||
PubMed ID: | 38523480 | ||||||
Web of Science ID: | WOS:001190717500001 | ||||||
Go to PubMed abstract | |||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/116504 | ||||||
Publisher's version: | https://doi.org/10.1080/10408363.2024.2319578 |
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