Chikh, A; Raimondi, C
(2024)
Endothelial Neuropilin-1: a multifaced signal transducer with an emerging role in inflammation and atherosclerosis beyond angiogenesis.
Biochem Soc Trans, 52 (1).
pp. 137-150.
ISSN 1470-8752
https://doi.org/10.1042/BST20230329
SGUL Authors: Chikh, Anissa
Abstract
Neuropilin-1 (NRP1) is a transmembrane glycoprotein expressed by several cell types including, neurons, endothelial cells (ECs), smooth muscle cells, cardiomyocytes and immune cells comprising macrophages, dendritic cells and T cell subsets. Since NRP1 discovery in 1987 as an adhesion molecule in the frog nervous system, more than 2300 publications on PubMed investigated the function of NRP1 in physiological and pathological contexts. NRP1 has been characterised as a coreceptor for class 3 semaphorins and several members of the vascular endothelial growth factor (VEGF) family. Because the VEGF family is the main regulator of blood and lymphatic vessel growth in addition to promoting neurogenesis, neuronal patterning, neuroprotection and glial growth, the role of NRP1 in these biological processes has been extensively investigated. It is now established that NRP1 promotes the physiological growth of new vessels from pre-existing ones in the process of angiogenesis. Furthermore, several studies have shown that NRP1 mediates signalling pathways regulating pathological vascular growth in ocular neovascular diseases and tumour development. Less defined are the roles of NRP1 in maintaining the function of the quiescent established vasculature in an adult organism. This review will focus on the opposite roles of NRP1 in regulating transforming growth factor β signalling pathways in different cell types, and on the emerging role of endothelial NRP1 as an atheroprotective, anti-inflammatory factor involved in the response of ECs to shear stress.
Item Type: |
Article
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Additional Information: |
© 2024 The Author(s)
This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). |
Keywords: |
adherens junction, atherosclerosis, cadherins, endothelial cells, neuropilins, transforming growth factors, Humans, Adult, Neuropilin-1, Vascular Endothelial Growth Factor A, Endothelial Cells, Angiogenesis, Inflammation, Atherosclerosis, Endothelial Cells, Humans, Inflammation, Vascular Endothelial Growth Factor A, Neuropilin-1, Adult, Atherosclerosis, Angiogenesis, 0601 Biochemistry and Cell Biology, 1101 Medical Biochemistry and Metabolomics, Biochemistry & Molecular Biology |
Journal or Publication Title: |
Biochem Soc Trans |
ISSN: |
1470-8752 |
Language: |
eng |
Dates: |
Date | Event |
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28 February 2024 | Published | 7 February 2024 | Published Online | 12 January 2024 | Accepted |
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Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
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PubMed ID: |
38323651 |
Web of Science ID: |
WOS:001158515500001 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/116485 |
Publisher's version: |
https://doi.org/10.1042/BST20230329 |
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