Precision Cardiology: Phenotype-targeted Therapies for HFmrEF and HFpEF.

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Rosano, GMC; Vitale, C; Spoletini, I (2024) Precision Cardiology: Phenotype-targeted Therapies for HFmrEF and HFpEF. Int J Heart Fail, 6 (2). pp. 47-55. ISSN 2636-1558 https://doi.org/10.36628/ijhf.2023.0058
SGUL Authors: Rosano, Giuseppe Massimo Claudio

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Official URL: https://doi.org/10.36628/ijhf.2023.0058

Abstract

Heart failure with mid-range ejection fraction (HFmrEF) and preserved ejection fraction (HFpEF) represent over half of heart failure cases but lack proven effective therapies beyond sodium-glucose cotransporter 2 inhibitor and diuretics. HFmrEF and HFpEF are heterogeneous conditions requiring precision phenotyping to enable tailored therapies. This review covers concepts on precision medicine approaches for HFmrEF and HFpEF. Areas discussed include HFmrEF mechanisms, anti-inflammatory and antifibrotic treatments for obesity-related HFpEF, If inhibition for HFpEF with atrial fibrillation, and mineralocorticoid receptor antagonism for chronic kidney disease-HFpEF. Incorporating precision phenotyping and matched interventions in HFmrEF and HFpEF trials will further advance therapy compared to blanket approaches.

Item Type:

Article

Additional Information:

© 2024. Korean Society of Heart Failure This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords:

Heart failure with mid-range ejection fraction (HFmrEF), Heart failure with preserved ejection fraction (HFpEF), Phenotypes, Precision cardiology

Journal or Publication Title:

Int J Heart Fail

ISSN:

2636-1558

Language:

eng

Dates: