Chambers, JC;
Zhang, W;
Lord, GM;
van der Harst, P;
Lawlor, DA;
Sehmi, JS;
Gale, DP;
Wass, MN;
Ahmadi, KR;
Bakker, SJL;
et al.
Chambers, JC; Zhang, W; Lord, GM; van der Harst, P; Lawlor, DA; Sehmi, JS; Gale, DP; Wass, MN; Ahmadi, KR; Bakker, SJL; Beckmann, J; Bilo, HJG; Bochud, M; Brown, MJ; Caulfield, MJ; Connell, JMC; Cook, HT; Cotlarciuc, I; Davey Smith, G; de Silva, R; Deng, G; Devuyst, O; Dikkeschei, LD; Dimkovic, N; Dockrell, M; Dominiczak, A; Ebrahim, S; Eggermann, T; Farrall, M; Ferrucci, L; Floege, J; Forouhi, NG; Gansevoort, RT; Han, X; Hedblad, B; Homan van der Heide, JJ; Hepkema, BG; Hernandez-Fuentes, M; Hypponen, E; Johnson, T; de Jong, PE; Kleefstra, N; Lagou, V; Lapsley, M; Li, Y; Loos, RJF; Luan, J; Luttropp, K; Maréchal, C; Melander, O; Munroe, PB; Nordfors, L; Parsa, A; Peltonen, L; Penninx, BW; Perucha, E; Pouta, A; Prokopenko, I; Roderick, PJ; Ruokonen, A; Samani, NJ; Sanna, S; Schalling, M; Schlessinger, D; Schlieper, G; Seelen, MAJ; Shuldiner, AR; Sjögren, M; Smit, JH; Snieder, H; Soranzo, N; Spector, TD; Stenvinkel, P; Sternberg, MJE; Swaminathan, R; Tanaka, T; Ubink-Veltmaat, LJ; Uda, M; Vollenweider, P; Wallace, C; Waterworth, D; Zerres, K; Waeber, G; Wareham, NJ; Maxwell, PH; McCarthy, MI; Jarvelin, M-R; Mooser, V; Abecasis, GR; Lightstone, L; Scott, J; Navis, G; Elliott, P; Kooner, JS
(2010)
Genetic loci influencing kidney function and chronic kidney disease.
Nat Genet, 42 (5).
pp. 373-375.
ISSN 1546-1718
https://doi.org/10.1038/ng.566
SGUL Authors: Dockrell, Mark Edward Carl
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Abstract
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
| Item Type: |
Article
|
| Additional Information: |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use (https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1038/ng.566 |
| Keywords: |
Biological Transport, Creatinine, Cystatin C, Europe, Gene Expression Regulation, Genetic Markers, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genotype, Glomerular Filtration Rate, Humans, Kidney, Kidney Failure, Chronic, Models, Genetic, Kidney, Humans, Kidney Failure, Chronic, Genetic Predisposition to Disease, Creatinine, Genetic Markers, Glomerular Filtration Rate, Gene Expression Regulation, Biological Transport, Genotype, Models, Genetic, Europe, Genetic Variation, Genome-Wide Association Study, Cystatin C, 06 Biological Sciences, 11 Medical and Health Sciences, Developmental Biology |
| SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
| Journal or Publication Title: |
Nat Genet |
| ISSN: |
1546-1718 |
| Language: |
eng |
| Dates: |
| Date | Event |
|---|
| May 2010 | Published | | 11 April 2010 | Published Online | | 15 March 2010 | Accepted |
|
| Publisher License: |
Publisher's own licence |
| Projects: |
|
| PubMed ID: |
20383145 |
| Web of Science ID: |
WOS:000277179500005 |
 |
Go to PubMed abstract |
| URI: |
https://openaccess.sgul.ac.uk/id/eprint/116233 |
| Publisher's version: |
https://doi.org/10.1038/ng.566 |
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