Hordijk, S; Carter, T; Bierings, R
(2024)
A new look at an old body: molecular determinants of Weibel-Palade body composition and von Willebrand factor exocytosis.
J Thromb Haemost, 22 (5).
pp. 1290-1303.
ISSN 1538-7836
https://doi.org/10.1016/j.jtha.2024.01.015
SGUL Authors: Carter, Thomas David
Abstract
Endothelial cells, forming a monolayer along blood vessels, intricately regulate vascular hemostasis, inflammatory responses, and angiogenesis. A key determinant of these functions is the controlled secretion of Weibel-Palade bodies (WPBs), which are specialized endothelial storage organelles housing a presynthesized pool of the hemostatic protein von Willebrand factor and various other hemostatic, inflammatory, angiogenic, and vasoactive mediators. This review delves into recent mechanistic insights into WPB biology, including the biogenesis that results in their unique morphology, the acquisition of intraluminal vesicles and other cargo, and the contribution of proton pumps to organelle acidification. Additionally, in light of a number of proteomic approaches to unravel the regulatory networks that control WPB formation and secretion, we provide a comprehensive overview of the WPB exocytotic machinery, including their molecular and cellular mechanisms.
Item Type: |
Article
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Additional Information: |
© 2024 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: |
Weibel-Palade bodies, endothelial cells, exocytosis, organelle biogenesis, von Willebrand factor, Weibel-Palade Bodies, Humans, Exocytosis, von Willebrand Factor, Animals, Endothelial Cells, Proteomics, Hemostasis, Weibel-Palade Bodies, Endothelial Cells, Animals, Humans, von Willebrand Factor, Proteomics, Exocytosis, Hemostasis, 1102 Cardiorespiratory Medicine and Haematology, 1103 Clinical Sciences, Cardiovascular System & Hematology |
Journal or Publication Title: |
J Thromb Haemost |
ISSN: |
1538-7836 |
Language: |
eng |
Dates: |
Date | Event |
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24 April 2024 | Published | 1 February 2024 | Published Online | 19 January 2024 | Accepted |
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Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
Project ID | Funder | Funder ID |
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LSBR-1707 | Landsteiner Stichting voor Bloedtransfusie Research | UNSPECIFIED | LSBR-2005 | Landsteiner Stichting voor Bloedtransfusie Research | UNSPECIFIED | MC_PC_13053 | Medical Research Council | http://dx.doi.org/10.13039/501100000265 |
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PubMed ID: |
38307391 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/116020 |
Publisher's version: |
https://doi.org/10.1016/j.jtha.2024.01.015 |
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