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Impact of maternal bariatric surgery on offspring perinatal cardiac function: A prospective study

Patey, O; Bartsota, M; Maric, T; Patel, D; Savvidou, M; Carvalho, JS (2024) Impact of maternal bariatric surgery on offspring perinatal cardiac function: A prospective study. BJOG: An International Journal of Obstetrics & Gynaecology, 131 (8). pp. 1080-1088. ISSN 1470-0328 https://doi.org/10.1111/1471-0528.17747
SGUL Authors: Carvalho, Julene

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Abstract

Objective To assess perinatal cardiac function in offspring of women with previous bariatric surgery and examine its association with maternal glucose control. Design Prospective study. Setting Maternity unit, UK. Population Fifty-four fetuses/neonates; 29 of post-bariatric surgery women and 25 of women without surgery. Methods Prospective, longitudinal observational study of pregnant women with and without previous bariatric surgery, matched for early pregnancy body mass index. Cardiac function of all offspring was assessed by two-dimensional conventional, spectral tissue Doppler and speckle-tracking echocardiography at 35–37 weeks of gestation and at 5–7 weeks of age. Maternal glycated haemoglobin (HbA1c) was measured at 27–30 weeks of gestation. Maternal demographics and fetal/infant cardiac function indices were compared between the groups. Correlation coefficient (r) is reported. Main outcome measures Fetal/infant cardiac function indices. Results Compared with no-bariatric neonates, offspring of post-bariatric women were smaller at birth (birthweight centiles: 64.96 ± 36.41 versus 40.17 ± 27.99; p = 0.007). There were no significant differences in fetal/infant cardiac function indices and perinatal cardiac changes, between groups. There was a positive correlation between maternal HbA1c and fetal left ventricular (LV) longitudinal strain (r = 0.33) and LV longitudinal strain rate (r = 0.29), suggesting an inverse relation between HbA1c and fetal LV systolic function, but this was mainly seen in offspring of women with no previous bariatric surgery (r = 0.56 and r = 0.50, respectively). Conclusions Maternal bariatric surgery does not appear to inadvertently affect the offspring cardiac performance. We found an inverse correlation between maternal HbA1c levels and fetal LV systolic function but this was mainly seen in the no-bariatric pregnancies.

Item Type: Article
Additional Information: © 2023 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: 11 Medical and Health Sciences, Obstetrics & Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: BJOG: An International Journal of Obstetrics & Gynaecology
ISSN: 1470-0328
Language: en
Dates:
DateEvent
3 June 2024Published
28 December 2023Published Online
13 December 2023Accepted
Publisher License: Creative Commons: Attribution 4.0
URI: https://openaccess.sgul.ac.uk/id/eprint/115954
Publisher's version: https://doi.org/10.1111/1471-0528.17747

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