Sayour, NV;
Paál, ÁM;
Ameri, P;
Meijers, WC;
Minotti, G;
Andreadou, I;
Lombardo, A;
Camilli, M;
Drexel, H;
Grove, EL;
et al.
Sayour, NV; Paál, ÁM; Ameri, P; Meijers, WC; Minotti, G; Andreadou, I; Lombardo, A; Camilli, M; Drexel, H; Grove, EL; Dan, GA; Ivanescu, A; Semb, AG; Savarese, G; Dobrev, D; Crea, F; Kaski, JC; de Boer, RA; Ferdinandly, P; Varga, ZV
(2023)
Effects of heart failure pharmacotherapy on cancer: a narrative review of implicated pathways and pre-clinical and clinical evidence.
European Heart Journal.
ISSN 0195-668X
(In Press)
SGUL Authors: Kaski, Juan Carlos
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Abstract
Heart failure (HF) patients have a significantly higher risk of new-onset cancer and cancer-associated mortality, compared to subjects free of HF. While both the prevention and treatment of new-onset HF in patients with cancer have been investigated extensively, less is known about the prevention and treatment of new-onset cancer in patients with HF, and whether and how guideline directed medical therapy (GDMT) for HF should be modified when cancer is diagnosed in HF patients. The purpose of this review is to elaborate and discuss the effects of pillar HF pharmacotherapies, as well as digoxin and diuretics on cancer, and to identify areas for further research and novel therapeutic strategies. To this end, in this review (i) proposed effects and mechanisms of action of guideline-directed HF drugs on cancer derived from pre-clinical data will be described, (ii) the evidence from both observational studies and randomized controlled trials on the effects of GDMT on cancer incidence and cancer-related outcomes, as synthetized by meta-analyses will be reviewed, and (iii) considerations for future pre-clinical and clinical investigations will be provided.
Item Type: | Article | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Keywords: | 1102 Cardiorespiratory Medicine and Haematology, 1103 Clinical Sciences, Cardiovascular System & Hematology | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | European Heart Journal | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
ISSN: | 0195-668X | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Publisher License: | Publisher's own licence | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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URI: | https://openaccess.sgul.ac.uk/id/eprint/115917 |
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