Snoek, L; Karampatsas, K; Bijlsma, MW; Henneke, P; Jauneikaite, E; Khan, UB; Zadoks, RN; Le Doare, K
(2023)
Meeting report: Towards better risk stratification, prevention and therapy of invasive GBS disease, ESPID research meeting May 2022.
Vaccine, 41 (42).
pp. 6137-6142.
ISSN 1873-2518
https://doi.org/10.1016/j.vaccine.2023.09.014
SGUL Authors: Le Doare, Kirsty
![]() |
Microsoft Word (.docx)
Accepted Version
Restricted to Repository staff only until 10 September 2024. Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (174kB) |
Abstract
The European Society of Pediatric Infectious Diseases (ESPID) hosted the third Group B Streptococcus (GBS) Research Session in Athens on 11th May 2022, providing researchers and clinicians from around the world an opportunity to share and discuss recent advances in GBS pathophysiology, molecular and genetic epidemiology and how these new insights can help in improving prevention and control of early- and late-onset GBS disease. The meeting provided a state-of-the-art overview of the existing GBS prevention strategies and their limitations, and an opportunity to share the latest research findings. The first presentation provided an overview of current GBS prevention and treatment strategies. In the second presentation, the genomic and antimicrobial resistance profiles of invasive and colonizing GBS strains were presented. The third presentation explained the association of intrapartum antibiotic prophylaxis (IAP) with the development of late-onset disease (LOD) and the interplay of host innate immunity and GBS. The fourth presentation evaluated the role of genomics in understanding horizontal GBS transmission. The fifth presentation focused on the zoonotic links for certain GBS lineages and the last presentation described the protective role of breastmilk. Talks were followed with interactive discussions and concluded with recommendations on what is needed to further GBS clinical research; these included: (i) the development of better risk stratification methods by combining GBS virulence factors, serological biomarkers and clinical risk factors; (ii) further studies on the interplay of perinatal antimicrobials, disturbances in the development of host immunity and late-onset GBS disease; (iii) routine submission of GBS isolates to reference laboratories to help in detecting potential clusters by using genomic sequencing; (iv) collaboration in animal and human GBS studies to detect and prevent the emergence of new pathogenic sequence types; and (v) harnessing the plethora of immune factors in the breastmilk to develop adjunct therapies.
Item Type: | Article | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Additional Information: | © 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | ||||||||||
Keywords: | Early-onset disease, Group B Streptococcus, Infant, Invasive GBS disease, Late-onset disease, Neonate, Risk-stratification, Zoonosis, Early-onset disease, Group B Streptococcus, Infant, Invasive GBS disease, Late-onset disease, Neonate, Risk-stratification, Zoonosis, 06 Biological Sciences, 07 Agricultural and Veterinary Sciences, 11 Medical and Health Sciences, Virology | ||||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) | ||||||||||
Journal or Publication Title: | Vaccine | ||||||||||
ISSN: | 1873-2518 | ||||||||||
Language: | eng | ||||||||||
Dates: |
|
||||||||||
Publisher License: | Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 | ||||||||||
Projects: |
|
||||||||||
PubMed ID: | 37699783 | ||||||||||
Go to PubMed abstract | |||||||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/115813 | ||||||||||
Publisher's version: | https://doi.org/10.1016/j.vaccine.2023.09.014 |
Statistics
Actions (login required)
![]() |
Edit Item |