Mendzelevski, B; Spencer, CS; Freier, A; Camilleri, D; Graff, C; Täubel, J
(2021)
Comparing the consistency of electrocardiogram interval measurements by resting ECG versus 12-lead Holter.
Ann Noninvasive Electrocardiol, 26 (5).
ISSN 1542-474X
https://doi.org/10.1111/anec.12851
SGUL Authors: Taubel, Jorg
Abstract
In clinical trials, traditionally only a limited number of 12-lead resting electrocardiograms (ECGs) can be recorded and, thus, long intervals may elapse between assessment timepoints and valuable information may be missed during times when patients' cardiac electrical activity is not being monitored. These limitations have led to the increasing use of Holter recorders which provide continuous data registrations while reducing the burden on patients and freeing up time for clinical trial staff to perform other tasks. However, there is a shortage of data comparing the two approaches. In this study, data from a randomized, double-blind, four-period, crossover thorough QT study in 40 healthy subjects were used to compare continuous 12-lead Holter recordings to standard 12-lead resting ECGs which were recorded in parallel. Heart rate and QT interval data were estimated by averaging three consecutive heartbeats. Values exceeding the sample average by more than 5% were tagged as outliers and excluded from the analysis. Visual comparisons of the ECG waveforms of the Holter signal showed a good correlation with resting ECGs at matching timepoints. Resting ECG data revealed sex differences that Holter data did not show. Specifically, women were found to have a longer QTcF of 20 ms, while men had a lower heart rate. We found that continuous recordings provided a more accurate reflection of changes in cardiac electrical activity over 24 hr. However, manual adjudication is still required to ensure the quality and accuracy of ECG data, and that only artifacts are removed thereby avoiding loss of true signals.
Item Type: |
Article
|
Additional Information: |
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.© 2021 The Authors. |
Keywords: |
AMPS/BRAVO, GE Getemed, Holter, QT/cQT, resting ECG, Cross-Over Studies, Double-Blind Method, Electrocardiography, Electrocardiography, Ambulatory, Female, Heart Rate, Humans, Male, Humans, Electrocardiography, Electrocardiography, Ambulatory, Cross-Over Studies, Double-Blind Method, Heart Rate, Female, Male, AMPS, BRAVO, GE Getemed, Holter, QT, cQT, resting ECG, 1102 Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology |
SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
Journal or Publication Title: |
Ann Noninvasive Electrocardiol |
Article Number: |
e12851 |
ISSN: |
1542-474X |
Language: |
eng |
Dates: |
Date | Event |
---|
2 September 2021 | Published | 22 March 2021 | Accepted | 4 May 2021 | Published Online |
|
Publisher License: |
Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 |
PubMed ID: |
33949017 |
Web of Science ID: |
WOS:000646891800001 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/115594 |
Publisher's version: |
https://doi.org/10.1111/anec.12851 |
Statistics
Item downloaded times since 07 Aug 2023.
Actions (login required)
![Edit Item](/style/images/action_view.png) |
Edit Item |