Liu, Y; Li, Y; Hu, Q
(2023)
Advances in saRNA Vaccine Research against Emerging/Re-Emerging Viruses.
Vaccines (Basel), 11 (7).
p. 1142.
ISSN 2076-393X
https://doi.org/10.3390/vaccines11071142
SGUL Authors: Hu, Qinxue
Abstract
Although conventional vaccine approaches have proven to be successful in preventing infectious diseases in past decades, for vaccine development against emerging/re-emerging viruses, one of the main challenges is rapid response in terms of design and manufacture. mRNA vaccines can be designed and produced within days, representing a powerful approach for developing vaccines. Furthermore, mRNA vaccines can be scaled up and may not have the risk of integration. mRNA vaccines are roughly divided into non-replicating mRNA vaccines and self-amplifying RNA (saRNA) vaccines. In this review, we provide an overview of saRNA vaccines, and discuss future directions and challenges in advancing this promising vaccine platform to combat emerging/re-emerging viruses.
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