Andersen, AR;
Urhoj, SK;
Tan, J;
Cavero‐Carbonell, C;
Gatt, M;
Gissler, M;
Klungsoyr, K;
Khoshnood, B;
Morris, J;
Neville, AJ;
et al.
Andersen, AR; Urhoj, SK; Tan, J; Cavero‐Carbonell, C; Gatt, M; Gissler, M; Klungsoyr, K; Khoshnood, B; Morris, J; Neville, AJ; Pierini, A; Scanlon, I; de Walle, HEK; Wellesley, D; Garne, E; Loane, M
(2023)
The burden of disease for children born alive with Turner syndrome—A European cohort study.
Birth Defects Research, 115 (16).
pp. 1459-1468.
ISSN 2472-1727
https://doi.org/10.1002/bdr2.2222
SGUL Authors: Tan, Joachim Wei Li Morris, Joan Katherine
Abstract
Background
Turner syndrome is a rare congenital anomaly caused by complete or partial X chromosome monosomy that may affect mortality and morbidity in childhood.
Methods
This population-based data-linkage cohort study, as part of the EUROlinkCAT project, investigated mortality and morbidity for the first 5 years of life for liveborn European children diagnosed with Turner syndrome. Thirteen population-based registries in 10 countries from the European surveillance of congenital anomalies (EUROCAT) network participated. Data on children born 1995–2014 and diagnosed with Turner syndrome were linked to mortality, hospital and prescription records. Children with any congenital anomaly and children without a congenital anomaly were included for comparison on morbidity.
Results
Out of a population of 5.8 million livebirths 404 were diagnosed with Turner syndrome prenatally or in infancy and 95.5% survived to their fifth birthday. During the first year of life 72.3% (95% CI 59.5;81.6) of children with Turner syndrome were hospitalized, the median length of stay was 5.6 days (95% CI 3.5;7.7) and 18.7% (95% CI 13.9;23.9) underwent surgery. After the first year of life hospitalizations and length of stay decreased but more children underwent surgery (30.8% [95% CI 17.6;44.7]). In the first 5 years the percentage of children with Turner syndrome having a prescription for antibiotics was 12%–20% per year and increased with the age of child.
Conclusions
In the first year of life, the burden of disease was relatively high for children with Turner syndrome. The outlook is more positive beyond the first year, though overall morbidity still exceeded that of children without congenital anomalies.
Item Type: |
Article
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Additional Information: |
© 2023 The Authors. Birth Defects Research published by Wiley Periodicals LLC.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
SGUL Research Institute / Research Centre: |
Academic Structure > Population Health Research Institute (INPH) |
Journal or Publication Title: |
Birth Defects Research |
ISSN: |
2472-1727 |
Language: |
en |
Dates: |
Date | Event |
---|
2 October 2023 | Published | 26 July 2023 | Published Online | 27 June 2023 | Accepted |
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Publisher License: |
Creative Commons: Attribution-Noncommercial 4.0 |
Projects: |
|
URI: |
https://openaccess.sgul.ac.uk/id/eprint/115571 |
Publisher's version: |
https://doi.org/10.1002/bdr2.2222 |
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