Dharmapalan, D; Bielicki, J; Sharland, M
(2023)
Harmonization of Amoxicillin Dose, Duration, and Formulation for Acute Childhood Respiratory Infections.
Antibiotics, 12 (7).
p. 1138.
ISSN 2079-6382
https://doi.org/10.3390/antibiotics12071138
SGUL Authors: Sharland, Michael Roy
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Abstract
Pediatric guidelines vary in their recommended amoxicillin dosing for common respiratory infections. It would help program delivery if there was harmonization of dosing and formulation of amoxicillin across multiple clinical respiratory infections, considering the pharmacokinetics, common targets, drug resistance, availability, cost effectiveness, and ease of administration. The World Health Organization EML AWaRe Book recommends higher dose amoxicillin given twice daily for five days for all uncomplicated respiratory infections where an antibiotic is indicated. The WHO AWaRe Book amoxicillin dosing guidance can be achieved for infants and older children using only scored 250 mg and 500 mg dispersible tablets (DTs), the WHO recommended child formulation. There is a clear need for wider availability of 250 mg/500 mg dispersible tablets of amoxicillin in both public and private health care sectors, to improve access to essential antibiotics.
Item Type: | Article |
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Additional Information: | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: | Antibiotics |
ISSN: | 2079-6382 |
Language: | en |
Publisher License: | Creative Commons: Attribution 4.0 |
URI: | https://openaccess.sgul.ac.uk/id/eprint/115534 |
Publisher's version: | https://doi.org/10.3390/antibiotics12071138 |
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