Baldwin, SN; Jepps, TA; Greenwood, IA
(2023)
Cycling matters: Sex hormone regulation of vascular potassium channels.
Channels (Austin), 17 (1).
p. 2217637.
ISSN 1933-6969
https://doi.org/10.1080/19336950.2023.2217637
SGUL Authors: Greenwood, Iain Andrew
Abstract
Sex hormones and the reproductive cycle (estrus in rodents and menstrual in humans) have a known impact on arterial function. In spite of this, sex hormones and the estrus/menstrual cycle are often neglected experimental factors in vascular basic preclinical scientific research. Recent research by our own laboratory indicates that cyclical changes in serum concentrations of sex -hormones across the rat estrus cycle, primary estradiol, have significant consequences for the subcellular trafficking and function of KV. Vascular potassium channels, including KV, are essential components of vascular reactivity. Our study represents a small part of a growing field of literature aimed at determining the role of sex hormones in regulating arterial ion channel function. This review covers key findings describing the current understanding of sex hormone regulation of vascular potassium channels, with a focus on KV channels. Further, we highlight areas of research where the estrus cycle should be considered in future studies to determine the consequences of physiological oscillations in concentrations of sex hormones on vascular potassium channel function.
Item Type: |
Article
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Additional Information: |
© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
Keywords: |
estrogens, estrus cycle, ion channels, progesterone, testosterone, vascular biology, Female, Humans, Rats, Animals, Progesterone, Potassium Channels, Gonadal Steroid Hormones, Estradiol, Menstrual Cycle, Animals, Humans, Rats, Estradiol, Progesterone, Gonadal Steroid Hormones, Potassium Channels, Menstrual Cycle, Female, ion channels, vascular biology, estrus cycle, estrogens, progesterone, testosterone, 0299 Other Physical Sciences, 0604 Genetics, Biochemistry & Molecular Biology |
SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
Journal or Publication Title: |
Channels (Austin) |
ISSN: |
1933-6969 |
Language: |
eng |
Dates: |
Date | Event |
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December 2023 | Published | 27 May 2023 | Published Online | 19 May 2023 | Accepted |
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Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
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PubMed ID: |
37243715 |
Web of Science ID: |
WOS:000994861000001 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/115520 |
Publisher's version: |
https://doi.org/10.1080/19336950.2023.2217637 |
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