Meroni, A; Mascherpa, M; Minopoli, M; Lambton, B; Elkalaawy, R; Frick, A; Thilaganathan, B
(2023)
Is mid-gestational uterine artery Doppler still useful in a setting with routine first-trimester pre-eclampsia screening? A cohort study.
BJOG, 130 (9).
pp. 1128-1134.
ISSN 1471-0528
https://doi.org/10.1111/1471-0528.17441
SGUL Authors: Thilaganathan, Baskaran
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Abstract
Objective To evaluate whether routine mid-gestational uterine artery Doppler (UtAD) modifies the risk for preterm pre-eclampsia after first-trimester combined pre-eclampsia screening. Design Retrospective cohort study. Setting London Tertiary Hospital. Population A cohort of 7793 women with singleton pregnancies, first-trimester pre-eclampsia screening using the Fetal Medicine Foundation (FMF) algorithm and UtAD pulsatility index (PI) assessment at the mid-gestation ultrasound. Methods Pregnancies were divided into four groups: high risk in both trimesters (H1H2), high risk in the first but not in the second trimester (H1L2), low risk in the first but high risk in the second trimester (L1H2) and low risk in both trimesters (L1L2). Main outcome measures Small for gestational age (SGA), hypertensive disorders of pregnancy (HDP) and stillbirth. Results In this cohort, 600 (7.7%) and 620 (7.9%) women were designated as being at high risk in the first and second trimesters, respectively. Preterm pre-eclampsia was more prevalent in the H1L2 group (4.5%) than in women considered at low risk in the first trimester (0.4%, p < 0.0001). The prevalence of preterm pre-eclampsia in the L1H2 group (3.3%) was significantly lower than that in women considered at high risk in the first trimester (7.0%, p = 0.0076), and was higher than that observed in the L1L2 group (0.2%, p < 0.0001). The prevalence of SGA and term HDP followed similar trends. Conclusions Pre-eclampsia risk after first-trimester FMF pre-eclampsia screening may be stratified through mid-gestational routine UtAD assessment. Pregnancy care should not be de-escalated for low mid-gestational UtAD resistance in women classified as being at high risk in the first trimester. The escalation of care may be justified in women at low risk but with high mid-gestational UtAD resistance.
Item Type: | Article | ||||||||
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Additional Information: | © 2023 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | ||||||||
Keywords: | Hypertensive Disorders of Pregnancy, Small for Gestational Age, Stillbirth, Uterine artery Doppler, first trimester preeclampsia screening, placenta-related adverse outcomes, first trimester preeclampsia screening, Hypertensive Disorders of Pregnancy, placenta-related adverse outcomes, Small for Gestational Age, Stillbirth, Uterine artery Doppler, 11 Medical and Health Sciences, Obstetrics & Reproductive Medicine | ||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) | ||||||||
Journal or Publication Title: | BJOG | ||||||||
ISSN: | 1471-0528 | ||||||||
Language: | eng | ||||||||
Dates: |
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Publisher License: | Creative Commons: Attribution-Noncommercial 4.0 | ||||||||
PubMed ID: | 36852521 | ||||||||
Go to PubMed abstract | |||||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/115206 | ||||||||
Publisher's version: | https://doi.org/10.1111/1471-0528.17441 |
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