Ratcliffe, H;
Tiley, KS;
Andrews, N;
Amirthalingam, G;
Vichos, I;
Morey, E;
Douglas, NL;
Marinou, S;
Plested, E;
Aley, P;
et al.
Ratcliffe, H; Tiley, KS; Andrews, N; Amirthalingam, G; Vichos, I; Morey, E; Douglas, NL; Marinou, S; Plested, E; Aley, P; Galiza, EP; Faust, SN; Hughes, S; Murray, CS; Roderick, M; Shackley, F; Oddie, SJ; Lees, T; Turner, DPJ; Raman, M; Owens, S; Turner, P; Cockerill, H; Lopez Bernal, J; Linley, E; Borrow, R; Brown, K; Ramsay, ME; Voysey, M; Snape, MD
(2023)
Community seroprevalence of SARS-CoV-2 in children and adolescents in England, 2019-2021.
Arch Dis Child, 108 (2).
pp. 123-130.
ISSN 1468-2044
https://doi.org/10.1136/archdischild-2022-324375
SGUL Authors: Galiza, Eva Princess
Abstract
OBJECTIVE: To understand community seroprevalence of SARS-CoV-2 in children and adolescents. This is vital to understanding the susceptibility of this cohort to COVID-19 and to inform public health policy for disease control such as immunisation. DESIGN: We conducted a community-based cross-sectional seroprevalence study in participants aged 0-18 years old recruiting from seven regions in England between October 2019 and June 2021 and collecting extensive demographic and symptom data. Serum samples were tested for antibodies against SARS-CoV-2 spike and nucleocapsid proteins using Roche assays processed at UK Health Security Agency laboratories. Prevalence estimates were calculated for six time periods and were standardised by age group, ethnicity and National Health Service region. RESULTS: Post-first wave (June-August 2020), the (anti-spike IgG) adjusted seroprevalence was 5.2%, varying from 0.9% (participants 10-14 years old) to 9.5% (participants 5-9 years old). By April-June 2021, this had increased to 19.9%, varying from 13.9% (participants 0-4 years old) to 32.7% (participants 15-18 years old). Minority ethnic groups had higher risk of SARS-CoV-2 seropositivity than white participants (OR 1.4, 95% CI 1.0 to 2.0), after adjusting for sex, age, region, time period, deprivation and urban/rural geography. In children <10 years, there were no symptoms or symptom clusters that reliably predicted seropositivity. Overall, 48% of seropositive participants with complete questionnaire data recalled no symptoms between February 2020 and their study visit. CONCLUSIONS: Approximately one-third of participants aged 15-18 years old had evidence of antibodies against SARS-CoV-2 prior to the introduction of widespread vaccination. These data demonstrate that ethnic background is independently associated with risk of SARS-CoV-2 infection in children. TRIAL REGISTRATION NUMBER: NCT04061382.
Item Type: |
Article
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Additional Information: |
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
Keywords: |
COVID-19, epidemiology, healthcare disparities, paediatrics, COVID-19, epidemiology, healthcare disparities, paediatrics, 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine, 1117 Public Health and Health Services, Pediatrics |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Arch Dis Child |
ISSN: |
1468-2044 |
Language: |
eng |
Dates: |
Date | Event |
---|
19 January 2023 | Published | 20 July 2022 | Published Online | 23 June 2022 | Accepted |
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Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
|
PubMed ID: |
35858775 |
Web of Science ID: |
WOS:000829978000001 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/114997 |
Publisher's version: |
https://doi.org/10.1136/archdischild-2022-324375 |
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