Ercoli, T;
Tinazzi, M;
Geroin, C;
Marcuzzo, E;
Erro, R;
Cuoco, S;
Ceravolo, R;
Mazzucchi, S;
Pilotto, A;
Padovani, A;
et al.
Ercoli, T; Tinazzi, M; Geroin, C; Marcuzzo, E; Erro, R; Cuoco, S; Ceravolo, R; Mazzucchi, S; Pilotto, A; Padovani, A; Romito, LM; Eleopra, R; Zappia, M; Nicoletti, A; Dallocchio, C; Arbasino, C; Bono, F; Spano, G; Demartini, B; Gambini, O; Modugno, N; Olivola, E; Bonanni, L; Albanese, A; Ferrazzano, G; Tessitore, A; Lopiano, L; Calandra-Buonaura, G; Petracca, M; Morgante, F; Esposito, M; Pisani, A; Manganotti, P; Tesolin, L; Teatini, F; Stocchi, F; Defazio, G
(2022)
Do demographic and clinical features and comorbidities affect the risk of spread to an additional body site in functional motor disorders?
J Neural Transm (Vienna), 129 (10).
pp. 1271-1276.
ISSN 1435-1463
https://doi.org/10.1007/s00702-022-02537-x
SGUL Authors: Morgante, Francesca
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Abstract
The aim of this study is to assess changes in the body distribution and the semeiology of functional motor disorder (FMD) in patients who reported only one or more than one body site affected at FMD onset. Data were obtained from the Italian Registry of Functional Motor Disorders, which included patients with a diagnosis of clinically definite FMDs. The relationship between FMD features and spread to other body sites was estimated by multivariate Cox regression analysis. We identified 201 (49%) patients who reported only one body site affected at FMD onset and 209 (51%) who reported multiple body sites affected at onset. FMD spread from the initial site to another site in 43/201 (21.4%) patients over 5.7 ± 7.1 years in those with only one site affected at FMD onset; FMD spread to an another body site in 29/209 (13.8%) over 5.5 ± 6.5 years. The spread of FMD was associated with non-motor functional symptoms and psychiatric comorbidities only in the patients with one body site affected at FMD onset. Our findings provide novel insight into the natural history of FMD. The number of body sites affected at onset does not seem to have a consistent influence on the risk of spread. Furthermore, our findings suggest that psychiatric comorbidities and non-motor functional symptoms may predict the spread of FMD symptoms, at least in patients with one body site affected at onset.
Item Type: | Article | ||||||||
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Additional Information: | © The Author(s) 2022 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | ||||||||
Keywords: | Functional motor disorders, Functional neurological disorders, Outcome, Phenotypic change, Spread, Demography, Humans, Motor Disorders, Movement Disorders, Humans, Movement Disorders, Demography, Motor Disorders, Functional neurological disorders, Functional motor disorders, Phenotypic change, Spread, Outcome, 1109 Neurosciences, 1701 Psychology, Neurology & Neurosurgery | ||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) | ||||||||
Journal or Publication Title: | J Neural Transm (Vienna) | ||||||||
ISSN: | 1435-1463 | ||||||||
Language: | eng | ||||||||
Dates: |
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Publisher License: | Creative Commons: Attribution 4.0 | ||||||||
PubMed ID: | 35972697 | ||||||||
Web of Science ID: | WOS:000841060900001 | ||||||||
Go to PubMed abstract | |||||||||
URI: | https://openaccess.sgul.ac.uk/id/eprint/114948 | ||||||||
Publisher's version: | https://doi.org/10.1007/s00702-022-02537-x |
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