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Autonomic dysfunction in progressive supranuclear palsy.

Baschieri, F; Vitiello, M; Cortelli, P; Calandra-Buonaura, G; Morgante, F (2023) Autonomic dysfunction in progressive supranuclear palsy. J Neurol, 270 (1). pp. 109-129. ISSN 1432-1459
SGUL Authors: Morgante, Francesca

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BACKGROUND: The degree of involvement of the autonomic nervous system in progressive supranuclear palsy (PSP) has been investigated in several studies, often providing conflicting results. There is a need for a better characterization of autonomic dysfunction in PSP, to enhance our understanding of this highly disabling neurodegenerative disease including patients' needs and possibly be of value for clinicians in the differential diagnosis among Parkinsonian syndromes. METHODS: We applied a systematic methodology to review existing literature on Pubmed regarding autonomic nervous system involvement in PSP. RESULTS: PSP reported quite frequently symptoms suggestive of autonomic dysfunction in all domains. Cardiovascular autonomic testing showed in some cases a certain degree of impairment (never severe). There was some evidence suggesting bladder dysfunction particularly in the storage phase. Dysphagia and constipation were the most common gastrointestinal symptoms. Instrumental tests seemed to confirm sudomotor and pupillomotor disturbances. CONCLUSIONS: PSP patients frequently reported visceral symptoms, however objective testing showed that not always these reflected actual autonomic impairment. Further studies are needed to better delineate autonomic profile and its prognostic role in PSP.

Item Type: Article
Additional Information: © The Author(s) 2022 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit
Keywords: Autonomic dysfunction, Orthostatic hypotension, Photophobia, Progressive supranuclear palsy, Urinary incontinence, Progressive supranuclear palsy, Autonomic dysfunction, Orthostatic hypotension, Urinary incontinence, Photophobia, 1103 Clinical Sciences, 1109 Neurosciences, Neurology & Neurosurgery
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: J Neurol
ISSN: 1432-1459
Language: eng
January 2023Published
30 August 2022Published Online
17 August 2022Accepted
Publisher License: Creative Commons: Attribution 4.0
PubMed ID: 36042018
Web of Science ID: WOS:000847618800002
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