Silvestro, M; Tessitore, A; Orologio, I; Sozio, P; Napolitano, G; Siciliano, M; Tedeschi, G; Russo, A
(2021)
Headache Worsening after COVID-19 Vaccination: An Online Questionnaire-Based Study on 841 Patients with Migraine.
J Clin Med, 10 (24).
ISSN 2077-0383
https://doi.org/10.3390/jcm10245914
SGUL Authors: Siciliano, Mattia
Abstract
Vaccines have represented the breakthrough in the fight against COVID-19. Based on reported headache attacks after vaccination in randomized controlled trials, we focused on the effects of COVID-19 vaccine administration on the migraine population, using an online questionnaire published on Italian Facebook groups oriented to headache patients. We collected data about the demographics and clinical parameters of migraine severity, COVID-19 infection, vaccination, and characteristics of headaches following vaccination. Out of 841 migraine patients filling in the questionnaire, 66.47% and 60.15% patients experienced a headache attack (from 1 hour to 7 days) after the first and the second vaccine dose, respectively. The main finding concerns headaches perceived by 57.60% of patients: attacks following vaccination were referred to as more severe (50.62% of patients), long-lasting (52.80% of patients) and hardwearing (49.69% of patients) compared to the usually experienced migraine attacks. This could be related to the production of inflammatory mediators such as type Iβ interferon. Considering the high prevalence of migraine in the general population, awareness of the possibility of headaches worsening following COVID-19 vaccination in these patients may allow both patients and clinicians to face this clinical entity with conscious serenity, and to reduce the waste of resources towards inappropriate health-care.
Item Type: |
Article
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Additional Information: |
Copyright: © 2021 by the authors.
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Keywords: |
COVID-19, headache, migraine with aura, migraine without aura, vaccine, migraine with aura, migraine without aura, COVID-19, vaccine, headache, 1103 Clinical Sciences |
SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
Journal or Publication Title: |
J Clin Med |
ISSN: |
2077-0383 |
Language: |
eng |
Dates: |
Date | Event |
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16 December 2021 | Published | 12 December 2021 | Accepted |
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Publisher License: |
Creative Commons: Attribution 4.0 |
PubMed ID: |
34945208 |
Web of Science ID: |
WOS:000743900200001 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/114896 |
Publisher's version: |
https://doi.org/10.3390/jcm10245914 |
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