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Nasopharyngeal carriage of pneumococcus in children in England up to ten years after PCV13 introduction: persistence of serotypes 3 and 19A and emergence of 7C.

Tiley, KS; Ratcliffe, H; Voysey, M; Jefferies, K; Sinclair, G; Carr, M; Colin-Jones, R; Smith, D; Bowman, J; Hart, T; et al. Tiley, KS; Ratcliffe, H; Voysey, M; Jefferies, K; Sinclair, G; Carr, M; Colin-Jones, R; Smith, D; Bowman, J; Hart, T; Kandasamy, R; Hinds, J; Gould, K; Berbers, G; Tcherniaeva, I; Robinson, H; Plested, E; Aley, P; Snape, MD (2023) Nasopharyngeal carriage of pneumococcus in children in England up to ten years after PCV13 introduction: persistence of serotypes 3 and 19A and emergence of 7C. J Infect Dis, 227 (5). pp. 610-621. ISSN 1537-6613 https://doi.org/10.1093/infdis/jiac376
SGUL Authors: Hinds, Jason

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Abstract

BACKGROUND: Monitoring changes in pharyngeal carriage of pneumococcus in children following 13-valent pneumococcal conjugate vaccine (PCV13) introduction in the UK in 2010 informs understanding of patterns of invasive pneumococcal disease (IPD) incidence. METHODS: Nasopharyngeal swabs from healthy children vaccinated with PCV13 according to schedule (2, 4, 12 months) were cultured and serotyped. Results for children aged 13-48 months were compared between 2014/15 and 2017/19, and with children aged 6-12 months (2017/20). Blood was obtained from a subset of children for pneumococcal serotype-specific IgG. RESULTS: Total pneumococcal carriage at 13-48 months was 47.9% (473/988) in 2014/15 and 51.8% (412/795) in 2017/19 (p = 0.10); at age 6-12 months this value was 44.6% (274/615). In 2017/19, 2.9% (95% CI 1.8-4.3%) of children aged 13-48 months carried PCV13 serotypes (mainly 3 (1.5%) and 19A (0.8%)) and over 20% carried the additional PCV20 serotypes. Similar proportions of children had IgG ≥0.35 IU/mL for each serotype in 2014/15 and 2017/19.Serotype 7C carriage increased significantly (p < 0.01) between 2014/15 and 2017/19. Carriage of PCV20 serotypes 8 and 12F, both major causes of IPD, was rare. DISCUSSION: Introduction of PCV20, if licensed for children, could significantly change the composition of pneumococcal serotypes carried in the pharynx of UK children.

Item Type: Article
Additional Information: © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Keywords: IPD, PCV, Pneumococcal, carriage, conjugate, invasive, nasopharyngeal, serotype, vaccine, 06 Biological Sciences, 11 Medical and Health Sciences, Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: J Infect Dis
ISSN: 1537-6613
Language: eng
Dates:
DateEvent
1 March 2023Published
21 September 2022Published Online
12 September 2022Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
PubMed ID: 36130327
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/114884
Publisher's version: https://doi.org/10.1093/infdis/jiac376

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