Bearne, LM;
Bieles, J;
Georgopoulou, S;
Andrews, J;
Tully, A;
Stolarchuk-Prowting, K;
Williamson, T;
Suarez, BS;
Nel, L;
D'Cruz, D;
et al.
Bearne, LM; Bieles, J; Georgopoulou, S; Andrews, J; Tully, A; Stolarchuk-Prowting, K; Williamson, T; Suarez, BS; Nel, L; D'Cruz, D; Lempp, H
(2020)
Fatigue in adults with primary antiphospholipid syndrome: findings from a mixed-methods study.
Lupus, 29 (8).
pp. 924-933.
ISSN 1477-0962
https://doi.org/10.1177/0961203320928421
SGUL Authors: Bearne, Lindsay Mary
Abstract
OBJECTIVE: This study aimed to explore the experience and impact of fatigue in adults with primary antiphospholipid syndrome (pAPS). METHODS: This sequential, explanatory mixed-methods study enrolled adults with a six-month or more history of pAPS. Consenting participants completed the Functional Assessment of Chronic Illness Therapy-Fatigue subscale (FS), Multi-Dimensional Perceived Social Support Scale, Patient Health Questionnaire (PHQ9), Pittsburgh Sleep Quality Index (PSQI), International Physical Activity Questionnaire (IPAQMETS). Relationships between FS and other variables were explored with multiple linear regression. Interviews were conducted with a subgroup of participants, and the data were analysed thematically. RESULTS: A total of 103 participants were recruited (Mage = 50.3 years; standard deviation = 10.1 years; 18 males). Of these, 62% reported severe fatigue. Greater fatigue was associated with lower mood, physical inactivity, poorer sleep quality and lower perceived social support. The best-fit model explained 56% of the variance in FS (adjusted R2 = 0.560, F(3, 74) = 33.65, p > 0.001) and included PHQ9 and IPAQMETS as significant predictors, and PSQI as a non-significant predictor. Twenty participants completed interviews. Three key themes were identified: characteristics of fatigue, impact on life and coping strategies. CONCLUSION: Fatigue was a common symptom of pAPS and challenging to manage. Other factors, particularly mood and physical activity, influenced fatigue. Evidence-based self-management interventions are needed.
Item Type: |
Article
|
Additional Information: |
© The Author(s) 2020.
This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
Keywords: |
Antiphospholipid syndrome, fatigue, mixed methods, Adaptation, Psychological, Adult, Antiphospholipid Syndrome, Cross-Sectional Studies, Exercise, Fatigue, Female, Humans, Linear Models, Male, Middle Aged, Multivariate Analysis, Surveys and Questionnaires, Humans, Antiphospholipid Syndrome, Fatigue, Exercise, Multivariate Analysis, Linear Models, Cross-Sectional Studies, Adaptation, Psychological, Adult, Middle Aged, Female, Male, Surveys and Questionnaires, Antiphospholipid syndrome, fatigue, mixed methods, 1103 Clinical Sciences, Arthritis & Rheumatology |
SGUL Research Institute / Research Centre: |
Academic Structure > Population Health Research Institute (INPH) |
Journal or Publication Title: |
Lupus |
ISSN: |
1477-0962 |
Language: |
eng |
Dates: |
Date | Event |
---|
July 2020 | Published | 5 June 2020 | Published Online | 30 April 2020 | Accepted |
|
Publisher License: |
Creative Commons: Attribution 4.0 |
PubMed ID: |
32501170 |
Web of Science ID: |
WOS:000538840500001 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/114798 |
Publisher's version: |
https://doi.org/10.1177/0961203320928421 |
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