Zargaran, A; Zargaran, D; Trompeter, AJ
(2021)
The role of Vitamin D in orthopaedic infection: a systematic literature review.
Bone Jt Open, 2 (9).
pp. 721-727.
ISSN 2633-1462
https://doi.org/10.1302/2633-1462.29.BJO-2020-0192.R1
SGUL Authors: Trompeter, Alex Joel
Abstract
AIMS: Orthopaedic infection is a potentially serious complication of elective and emergency trauma and orthopaedic procedures, with a high associated burden of morbidity and cost. Optimization of vitamin D levels has been postulated to be beneficial in the prevention of orthopaedic infection. This study explores the role of vitamin D in orthopaedic infection through a systematic review of available evidence. METHODS: A comprehensive search was conducted on databases including Medline and Embase, as well as grey literature such as Google Scholar and The World Health Organization Database. Pooled analysis with weighted means was undertaken. RESULTS: Pooled analysis of four studies including 651 patients found the mean 25(OH)D level to be 50.7 nmol/l with a mean incidence of infection of 70%. There was a paucity of literature exploring prophylactic 25(OH)D supplementation on reducing orthopaedic infection, however, there was evidence of association between low 25(OH)D levels and increased incidence of orthopaedic infection. CONCLUSION: The results indicate a significant proportion of orthopaedic patients have low 25(OH]D levels, as well as an association between low 25(OH)D levels and orthopaedic infection, but more randomized controlled trials need to be conducted to establish the benefit of prophylactic supplementation and the optimum regimen by dose and time. Cite this article: Bone Jt Open 2021;2(9):721-727.
Item Type: |
Article
|
Additional Information: |
© 2021 Author(s) et al. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND 4.0) licence, which permits the copying and redistribution of the work only, and provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Keywords: |
25[OH]D, Infection, Medline, Orthopaedic, Orthopaedic infection, Orthopaedic trauma, Outcomes, Vitamin D, infections, morbidity, orthopaedic procedures, periprosthetic joint infections (PJIs), randomized controlled trials, serum |
SGUL Research Institute / Research Centre: |
Academic Structure > Institute of Medical & Biomedical Education (IMBE) |
Journal or Publication Title: |
Bone Jt Open |
ISSN: |
2633-1462 |
Language: |
eng |
Dates: |
Date | Event |
---|
7 September 2021 | Published |
|
Publisher License: |
Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 |
PubMed ID: |
34488428 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/114592 |
Publisher's version: |
https://doi.org/10.1302/2633-1462.29.BJO-2020-0192.R1 |
Statistics
Item downloaded times since 28 Jul 2022.
Actions (login required)
![Edit Item](/style/images/action_view.png) |
Edit Item |